EMBARGOED FOR RELEASE UNTIL 4 PM ET, September 10, 2025
Can鈥檛 sleep? Insomnia associated with accelerated brain aging
MINNEAPOLIS 鈥 People with chronic insomnia may experience faster declines in memory and thinking skills as they age鈥攁long with brain changes that can be seen on imaging scans鈥攖han people who do not have chronic insomnia, according to a study published in the September 10, 2025, issue of , the medical journal of the 好色先生. The study found that people with chronic insomnia鈥攖rouble sleeping at least three days a week for three months or more鈥攈ad a 40% higher risk of developing mild cognitive impairment or dementia than those without insomnia, which is the equivalent of 3.5 additional years of aging. The study does not prove that insomnia causes brain aging, it only shows an association. 鈥淚nsomnia doesn鈥檛 just affect how you feel the next day鈥攊t may also impact your brain health over time,鈥 said study author Diego Z. Carvalho, MD, of the Mayo Clinic in Rochester, Minnesota, and a member of the 好色先生. 鈥淲e saw faster decline in thinking skills and changes in the brain that suggest chronic insomnia could be an early warning sign or even a contributor to future cognitive problems.鈥 The study tracked a group of cognitively healthy older adults鈥2,750 people with an average age of 70鈥攆or an average of 5.6 years. Of participants, 16% had chronic insomnia. At the start of the study, participants were asked whether they had been sleeping more or less than usual during the past two weeks. They also took yearly thinking and memory tests, and some had brain scans to look for white matter hyperintensities鈥攁reas where small vessel disease may have damaged brain tissue鈥攁nd for amyloid plaques, a protein that can build up and is linked to Alzheimer鈥檚 disease. During the study, 14% of the people with chronic insomnia developed mild cognitive impairment or dementia, compared to 10% of those who did not have insomnia. After accounting for factors like age, high blood pressure, use of sleep medications and a diagnosis of sleep apnea, they found that people with insomnia were 40% more likely to develop mild cognitive impairment or dementia than those without insomnia. They also had faster declines on tests measuring different thinking skills. Among those with insomnia, researchers determined the type: those getting less sleep than usual in the past two weeks; or those getting more sleep than usual in the past two weeks. People who reported getting less sleep than usual were more likely to have lower cognitive test scores at the beginning of the study, comparable to being four years older. They also had more white matter hyperintensities and amyloid plaques. For amyloid, the effect was similar to what is seen in people with the APOE e4 gene, a known genetic risk factor. People who reported getting more sleep than usual, on the other hand, were more likely to have fewer white matter hyperintensities at the start of the study. Some groups were especially vulnerable. Participants who carry the APOE e4 gene鈥攍inked to higher Alzheimer鈥檚 risk鈥攕howed steeper declines in memory and thinking skills. 鈥淥ur results suggest that insomnia may affect the brain in different ways, involving not only amyloid plaques, but also small vessels supplying blood to the brain,鈥 Carvalho said. 鈥淭his reinforces the importance of treating chronic insomnia鈥攏ot just to improve sleep quality but potentially to protect brain health as we age. Our results also add to a growing body of evidence that sleep isn鈥檛 just about rest鈥攊t鈥檚 also about brain resilience.鈥 A limitation of the study was that insomnia diagnoses came from medical records, which do not capture undiagnosed cases or reflect how severe symptoms are. The study was supported by the National Institutes of Health, GHR Foundation, Mayo Foundation for Medical 好色先生 and Research, and a grant from Sleep Number Corporation to the Mayo Clinic. Discover more about brain health at , from the 好色先生. This resource also offers a magazine, podcast, and books that connect patients, caregivers and anyone interested in brain health with the most trusted information, straight from the world鈥檚 leading experts in brain health. Follow Brain & Life庐 on , and .