Abstract Details

Title 7T Magnetic Resonance Spectroscopy in Idiopathic Parkinson Disease

Topic Movement Disorders

Presentation(s) S33 - (-)

Poster/Presentation
Number 003

Objective

Background Clinical subtypes of PD differ in presenting features, clinical course and response to pharmacotherapy. The neuroanatomical and neurometabolic differences underlying clinical manifestations of PD remain unclear. 1H-MRS is a non-invasive imaging technique which evaluates the neurochemical profile of anatomical regions to investigate patterns of change reflecting neuronal integrity and degeneration.

Design/Methods 1H-MRS metabolite spectra were acquired from tremor dominant (TD), akinetic rigid (AkR) PD patients and healthy controls using a 7-T system from 4 locations (bilateral SNc and STN; 1.3 x 1.3 x 1.3 cm3). The contribution of individual neurochemical metabolites (N-acetylaspartate, NAA; glutamate, Glu; glutamine, Gln; creatine, Cr; choline, Cho; and myo-inositol, mI) to each spectrum was determined and compared between groups and anatomical locations.

Results The data from 7 TD, 5 AkR and 5 control subjects demonstrate a significant effect of location, F(18,142) = 1.984, p=0.01, with a significant increase in NAA (NAA/Cr ratio) in left SNc of AkR patients compared to controls. No other significant differences between patient groups for other metabolites, locations or hemispheres were found.

Conclusions This unique study used 7T 1H-MRS to establish a possible neurochemical marker for PD phenotypes. Specifically, the NAA/Cr ratio in the SNc of AkR patients was increased (rather than decreased) relative to controls, suggesting an increase in NAA concentrations. These results raise interesting hypotheses that have previously been explored in animal models of PD, including the possibility of impaired regulation of NAA, or, compensatory increases in branching of axons in reaction to SNc neuronal cell loss.

Authors/Disclosures
Derek Debicki, MD PRESENTER	Dr. Debicki has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for UCB Canada Inc.. The institution of Dr. Debicki has received research support from Academic Medical Association of Southwestern Ontario. The institution of Dr. Debicki has received research support from Western BrainScan. The institution of Dr. Debicki has received research support from Lawson Research. The institution of Dr. Debicki has received research support from Canadian Institutes of Health Research.
	No disclosure on file
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Salvatore Lo Fermo	No disclosure on file
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Mandar S. Jog, MD, FAAN (University of Western Ontario)	Dr. Jog has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merz. Dr. Jog has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbvie. Dr. Jog has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Ipsen. Dr. Jog has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Abbvie. Dr. Jog has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Ipsen. Dr. Jog has stock in MDDT .

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