Abstract Details

Title SNP rs10940495 in the Gp-130 Locus Is Associated with Functional Outcome Following Spontaneous Intracerebral Hemorrhage

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) S41 - (-)

Poster/Presentation
Number 005

Objective

Background Genetic influences may play an important role in mediating outcome after acute brain injury.

Design/Methods Patients with spontaneous supratentorial ICH were enrolled prospectively from Duke University Hospital between 2009 and 2011. Ten preselected SNPs (rs2228145 [IL6R A/C], rs3219119 [PARP-1 A/T], rs1900173[gp130 A/T], rs10940495 [gp130 A/G], rs1800629 [TNF? A/G], rs2258689 [Tau exon6 H47Y C/T], rs10445337 [Tau exon6 S53P C/T], rs405509 [APOE promoter -219 G/T], rs429358 [APOE exon 4 C112R C/T], rs7412 [APOE exon 4 C158R C/T]) from six candidate genes were tested for associations with in-hospital deterioration (Glasgow Coma Scale decrease by >2 within 7 days of hospitalization), 6 month mortality, and 6 month functional outcome (mRS>2) following ICH. Fisher exact test and logistic regression with adjustment for race and ICH score were performed. p-value ? 0.05 was considered significant.

Results Fifty-five patients were enrolled [31 male, 29 white (25 black, 1 Hispanic), median age= 66, median ICH score on admission=1]. All markers met Hardy Weinberg equilibrium; no strong linkage disequilibrium between the markers was observed. Neither race nor ICH risk score were significant predictors for the 6 month mortality outcome. Fisher-exact tests revealed SNPs rs10940495 (gp130 G/A; p=0.019) and rs3219119 (PARP-1 A/T; p=0.038) significantly associated with 6 month mortality. ICH risk score was a significant predictor (p<0.05 for all markers), and SNP rs10940495 (gp-130 G/A, p=0.019) was the only SNP significantly associated with 6 month functional outcome. None of the SNPs were associated with in-hospital deterioration.

Conclusions Gp130 is a critical component of signal transduction in the IL-6 receptor that may influence inflammation. The association between SNP rs10940495 in the gp-130 locus and 6 months outcome following ICH in this exploratory study should be replicated in a larger study.

Authors/Disclosures
Nada El Husseini, MD, FAAN (DUKE UNIVERSITY HOSPITAL) PRESENTER	The institution of Dr. El Husseini has received research support from the DISCOVERY trial funded by the National Institute of Neurological Disorders and Stroke (NINDS)and the National Institute on Aging (NIA) (U19NS115388).- subcontract from MGH.
Daniel T. Laskowitz, MD	No disclosure on file
	No disclosure on file
	No disclosure on file
Tania Nikolcheva	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Michael L. James, MD (Duke University Medical Center)	Dr. James has nothing to disclose.

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