Abstract Details

Title Association of Triglyceride: High Density Lipoprotein Ratio with Intracranial Atherosclerotic Disease

Topic Interventional Neurology

Presentation(s) S46 - (-)

Poster/Presentation
Number 002

Objective

Background Emerging data suggest that a triglyceride high density lipoprotein (TG):HDL-C ratio may be a better predictor of vascular risk than the traditional lipid measures such as Total cholesterol and LDL-C.

Design/Methods We identified patients with angiographically diagnosed symptomatic intracranial atherosclerotic disease (ICAD) from a prospectively maintained registry supplemented by retrospective chart review between 2007 to 2010 (n=40). Patient's lipid profile performed within 3 months of diagnosis was analyzed. The ICAD cohort was matched by age and gender to a normal population (without any vascular events including transient ischemic attack, stroke or death due cardiovascular event) from the Multi-Ethnic Study of Atherosclerosis (MESA) database. The MESA which is a population-based sample of 6,800 men and women aged 45-84 years, prospectively monitored with 3 cross sectional follow up of normal individuals in six communities in the United States.

Results Case control continuous variable analysis showed significantly higher TG/HDL ratio in ICAD subjects as compared to Control subjects (4.81 ± 3.11 vs. 2.95 ± 1.95 p=0.0002). In a logistic regression model, higher TG/HDL ratio was directly associated with ICAD (odds ratio [OR] 1.36, 95% confidence interval [CI] 1.13-1.65 p= 0.001). After adjusting for diabetes, hypertension, smoking, cigarette smoking and alcohol use higher TG/HDL ratio was directly associated with ICAD (OR 1.26, 95% CI 1.0-1.58 p= 0.048).

Conclusions The serum TG: HDL-C ratio is associated with symptomatic ICAD. Further studies are needed to validate the use of TG: HDL-C ratio in risk stratification for population based screening and intervention.

Authors/Disclosures
Vishal Jani, MD (Creighton University Hospital / CHI Health) PRESENTER	Dr. Jani has nothing to disclose.
Gereon Nelles, MD, PhD, FAAN (Neurologische Praxis)	Dr. Nelles has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Industry. Dr. Nelles has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Industry. Dr. Nelles has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Industry. Dr. Nelles has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Industry. Dr. Nelles has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Industry. Dr. Nelles has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Industry. Dr. Nelles has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Industry. Dr. Nelles has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. The institution of Dr. Nelles has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Memodio. Dr. Nelles has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Industrial. Dr. Nelles has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Industry. Dr. Nelles has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Industry. Dr. Nelles has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Industry. Dr. Nelles has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Industry. Dr. Nelles has received personal compensation in the range of $5,000-$9,999 for serving as an officer or member of the Board of Directors for German Neurologists Professional Organization. Dr. Nelles has received publishing royalties from a publication relating to health care.
Saqib A. Chaudhry, MD	Dr. Chaudhry has nothing to disclose.
Anmar Razak, MD	Dr. Razak has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen Pharmaceuticals.
Syed I. Hussain, MD (Cleveland Clinic Abu Dhabi)	Dr. Hussain has nothing to disclose.
Hamza I. Maqsood, MD (Dept of Neurology)	Dr. Qureshi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for AstraZeneca.
	No disclosure on file

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