Abstract Details

Title Sleep Disturbance in Patients with Parkinson Disease Presenting with Leg Motor Restlessness

Topic Sleep

Presentation(s) P05 - (-)

Poster/Presentation
Number 028

Objective

Background BACKGROUND: The urge to move (UM), which is accompanied by an unpleasant sensation in the affected limbs, is a core symptom of restless leg syndrome (RLS). Patients with UM, though not fulfilling the essential RLS criteria, were diagnosed with LMR. A recent study showed that in early PD, LMR and not RLS occurs with a nearly 3-fold higher risk in UM patients than in controls (Neurology 2011;77:1941-1946). However, effects of LMR on sleep remain undetermined.

Design/Methods DESIGN/METHODS: Using questionnaires, we assessed 158 Japanese PD patients (male:female=65:93, 70.3±9.4 years) for LMR, sleep time, and insomnia including sleep-onset insomnia and arousal during sleep. RLS was diagnosed according to the essential diagnostic criteria. We also assessed excessive of daytime sleepiness (EDS) with the Epworth Sleepiness Scale.

Results RESULTS: Forty-eight patients had UM; 18 (11%) and 30 patients (19%) were diagnosed with RLS and LMR, respectively. Sleep time of the RLS group, LMR group, and non-UM group were 5.8±1.8 h, 6.5±1.7 h, and 7.0±1.5 h, respectively. Sleep time of RLS group was shorter than that of non-UM group (P=0.009). Frequencies of insomnia of the RLS, LMR, and non-UM groups were 77.7%, 63.3%, and 40.9%, respectively; frequencies of insomnia of the RLS and LMR groups were higher than that of non-UM group, respectively (P=0.004 and 0.029). Frequencies of EDS of the RLS, LMR, and non-UM groups were 61.1%, 46.7%, and 34.5%, respectively, and frequency of EDS of RLS group was higher than that of non-UM group (P=0.032).

Conclusions CONCLUSIONS: Sleep time, frequencies of insomnia, and EDS of LMR group were intermediate between those of RLS and non-UM groups. LMR might be a novel contributing factor to sleep disturbance in PD patients.

Authors/Disclosures
Takayoshi Shimohata, MD, FAAN (Department of Neurology, Gifu University) PRESENTER	Dr. Shimohata has nothing to disclose.
Masatoyo Nishizawa, MD (Niigata University of Health and Welfare)	No disclosure on file
	No disclosure on file

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