Abstract Details

Title The Prevalence of Parkinson Disease: A Systematic Review and Meta-Analysis

Topic Movement Disorders

Presentation(s) P03 - (-)

Poster/Presentation
Number 067

Objective

Background BACKGROUND: PD is a common neurodegenerative disorder. We sought to synthesize door-to-door studies on the prevalence of PD to obtain an overall view of how the epidemiology of this disease varies by age, by sex, and by geographic location.

Design/Methods DESIGN/METHODS: We searched MEDLINE and EMBASE for epidemiological studies of PD from 1985 to 2010. Two reviewers independently extracted data for all studies. Overall prevalence and stratified results by age and sex were recorded. To assess for significant between-study heterogeneity the Cochrane Q statistic was calculated and I2 was used to quantify the amount of between-study heterogeneity. When significant heterogeneity was absent, the pooled prevalence per 100,000 people and 95% confidence intervals were calculated using a fixed-effects model. When significant heterogeneity was present a random-effects model was used. Meta-regression was used to determine if a significant difference in the estimates were present by age, sex, or between geographic locations.

Results RESULTS: 47 studies were included in the analysis. There was a significant increase in PD prevalence with age, with a prevalence (all per 100,000) of 40.5 in 40-49 year olds, 106. 7 in 50-59 year olds, 428.5 in 60-69 year old, 1086.5 in 70-79 year olds, and 1903 in those 80 years and older. There was a significant difference in prevalence by geographic location only for individuals 70-79 years old, with a prevalence of 1601.0 in individuals from North America, Europe and Australia, compared to 645.6 in individuals from Asia (p<0.05). There was a significant difference in prevalence by sex only for individuals 50-59 years old, with a prevalence of 40.9 in females and 133.7 in males (p<0.05).

Conclusions CONCLUSIONS: PD prevalence increases steadily with age. Some differences in prevalence by geographic location and sex can be detected.

Authors/Disclosures
Tamara M. Pringsheim, MD, FAAN (Mathison Centre) PRESENTER	The institution of Dr. Pringsheim has received research support from Canadian Institutes of Health Research. The institution of Dr. Pringsheim has received research support from Azrieli Accelerator.
Nathalie Jette, MD, MSc, FRCPC, FAAN (University of Calgary)	Dr. Jette has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for ILAE Epilepsia. The institution of Dr. Jette has received research support from NIH. The institution of Dr. Jette has received research support from AES.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Thomas D. Steeves, MD (Vassar Brothers Medical Center)	No disclosure on file
Ludwig Kappos, MD, FAAN (RC2NB, University Hospital Basel)	Dr. Kappos has nothing to disclose.

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