Abstract Details

Title Early Optical Detection of Cerebral Edema In-Vivo

Topic Critical Care/Emergency Neurology/Trauma

Presentation(s) P03 - (-)

Poster/Presentation
Number 147

Objective

Background BACKGROUND: Cerebral edema in traumatic brain injury is associated with significant mortality and morbidity. The current clinical standard to detect cerebral edema is intracranial pressure (ICP) measurements. A direct, minimally invasive method to interrogate water movement would be a valuable tool in neurocritical care.

Design/Methods DESIGN/METHODS: A dual-fiberoptic probe was connected to a laser diode generating near-infrared light (850nm wavelength). The water intoxication model was used to induce cytotoxic cerebral edema. The fiberoptic probe was inserted into the brain of wild-type mice stereotactically. An ICP monitor was inserted contralaterally. A steady optical baseline was obtained before injecting water (30% body weight, i.p.) in the experimental animals and normal saline in control animals."Optical trigger" was calculated as two standard deviations reduction in optical signal. (Figure 1A,B & C - Not submitted in abstract).

Results RESULTS: The optical trigger was detected 31 minutes before the ICP measurements changed from baseline pressure of 3-6mm Hg to a pathological ICP of 20mm Hg (n=3,p<0.001). Significant change in optical signal was also detected well before ICP rises to 10 and 15mm Hg. The saline injected controls showed a steady optical baseline.

Conclusions CONCLUSIONS: We have validated a novel near-infrared optical probe to detect the early phase of cerebral edema. This type of detector could be clinically applicable to patients with various types of brain injury.

Authors/Disclosures
Kiran F. Rajneesh, MD, FAAN PRESENTER	An immediate family member of Dr. Rajneesh has stock in Crossliner.
Devin K. Binder	No disclosure on file
Astrid Scheschonka	No disclosure on file

��ɫ��

��ɫ��