好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Unilateral Perseveration
Behavioral Neurology
P01 - (-)
008
Motor perseveration, which has been subdivided into the continuous and recurrent subtypes, is a disengagement disorder, often induced by dysfunction of the executive frontal-subcortical networks that control the action-intentional programming system. Most prior reports have described bilateral upper limb perseveration.
Careful clinical evaluation as detailed in this case report revealed a patient with a parkinsonian syndrome with the unique feature of unilateral motor perseveration.
This 68 year old right-handed gentleman with impaired walking and vertical gaze, consistent with a diagnosis of progressive supranuclear palsy (PSP), had continuous perseveration of the right hand, but not the left hand, on multiple motor tasks.
Unilateral motor perseveration may be a sign of PSP or corticobasal degeneration (CBD) and future studies should use tasks that assess for this disorder. The mechanism underlying this disorder is not known, but patients with unilateral right frontal-subcortical disease are most likely to reveal bilateral perseveration. Patients with PSP and CBD have callosal degeneration and perhaps a callosal disconnection of the left hemisphere's premotor and motor areas from the right frontal lobe induced this disorder; however, further research will be needed to test this postulate.
Authors/Disclosures
Lealani M. Acosta, MD, MPH, FAAN (Vanderbilt University Medical Center)
PRESENTER 		Dr. Acosta has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alector. Dr. Acosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology. The institution of Dr. Acosta has received research support from AbbVie, Sage, NIH, Bristol Myers Squibb/Fortrea, CND Life Sciences.
Ira J. Goodman, MD (The Compass Clinic) No disclosure on file
Kenneth M. Heilman, MD, FAAN (Univ. of Florida, Dept. of Neurology) Dr. Heilman has received publishing royalties from a publication relating to health care.
Ralf Linker (Uniklinik Erlangen) Dr. Linker has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Linker has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer. The institution of Dr. Linker has received research support from Novartis. The institution of Dr. Linker has received research support from Biogen.