Abstract Details

Title Prevalence of Hepatitis B Virus in Primary Central Nervous System Lymphoma

Topic Neuro-oncology

Presentation(s) P07 - (-)

Poster/Presentation
Number 009

Objective

Background BACKGROUND: PCNSL is a particularly rare B cell Non-Hodgkin lymphoma (NHL), strictly localized in the brain, the leptomeninges, the eyes and the spine. In the immunocompromised patients, PCNSL is frequently associated with Epstein Barr Virus. Up to date, no association between this brain tumor and viruses has been pointed out in immunocompetent patients. Nevertheless, there are growing evidences that systemic B-NHL might be associated with HBV and Hepatitis C Virus (HCV).

Design/Methods DESIGN/METHODS: The medical records of 106 immunocompetent patients who were treated in our department between 2002 and 2012 for PCNSL were reviewed.

Results RESULTS: The sex ratio of the cohort was 1.3 (60 males/45 females) and the median age was 62 years (range: 16-84). None of the patients were infected by HCV. HBs Ag, anti-HBs Ab and anti-HBc Ab were detected in 2.8% (n=3), 29.2% (n=31) and 15.1% (n=16) of cases respectively. Although prevalences of HBsAg and anti-HBc Ab were not significantly different from what was observed in the greater Paris area (e.g. Ile de France) population (2.8% vs. 0.8%; p=0.07 regarding HBsAg; 15.1% vs. 10.8%; p=0.2 regarding anti-HBc Ab), there were a trend for higher HBsAg and anti-HBc Ab seroprevalences in PCNSL.

Conclusions CONCLUSIONS: This is the first study investigating Hepatitis virus infection in PCNSL patients. Although trends were observed, no statistically significant difference was found regarding prevalence of HBs Ag or anti-HBc Ab compared to the control population. Further studies using additional control population and enrolling a larger number of patients will be needed to study the association between HBV infection and PCNSL and the potential role of HBV in the development of these rare tumors.

Authors/Disclosures
Geraldine Faivre, MD (The Queens' Medical Center- West O'ahu) PRESENTER	Dr. Faivre has nothing to disclose.
	No disclosure on file
	No disclosure on file
Marc Sanson	No disclosure on file
Jean-Yves Delattre, MD (Hopital de la Salpetriene)	No disclosure on file
	No disclosure on file
	No disclosure on file
Mathias Maurer, MD	No disclosure on file

��ɫ��

��ɫ��