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Abstract Details

Impact of Meditation on Default Mode Network & Hippocampus in Mild Cognitive Impairment: A Randomized Trial
Aging and Dementia
P01 - (-)
014
Meditation has been associated with increased hippocampal density and default mode network (DMN) connectivity. While stress may be associated with development of cognitive impairment, little is known about the neurophysiological impact of meditation in this population.
14 adults 55-90 years with MCI were randomized to MBSR (8 weekly meditation/yoga classes) vs. usual care. We conducted resting state fMRI at baseline and 8 weeks and our primary outcomes were: 1) functional connectivity between hippocampus, medial prefrontal cortex (MPFC), and posterior cingulate (PCC), key regions of the DMN; 2) rate of hippocampal atrophy. The Alzheimer's Disease Assessment Scale, cognitive subscale (ADAS-cog) was a secondary outcome.
After the intervention, participants in the MBSR group had increased functional connectivity between the PCC and bilateral MPFC and left hippocampus compared to those in the control group. Those in the MBSR group had trends of less bilateral hippocampal atrophy than those in the control group (median hippocampal volume difference from baseline to follow-up in MBSR, -32 vs. -274 in control, p=0.07). No significant differences were detected for median change from baseline for MBSR vs. control in ADAS-cog (-0.5 vs. 0, p=0.46).
MBSR appears to be a feasible non-pharmacological intervention in adults with MCI that may have a positive impact on the regions of the brain most related to MCI and Alzheimer's disease. Further research is warranted.
Authors/Disclosures
Rebecca E. Wells, MD, FAAN (Wake Forest Bapttist Medical Center)
PRESENTER 		The institution of Dr. Wells has received research support from NIH. Dr. Wells has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Southern Headache Society. Dr. Wells has a non-compensated relationship as a Board member with Southern Headache Society that is relevant to AAN interests or activities. Dr. Wells has a non-compensated relationship as a Board member with American Headache Society that is relevant to AAN interests or activities.
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
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Krzysztof W. Selmaj (University of Warmia and Mazury) Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Astra. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for BMS. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Astra. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for BMS. Krzysztof W. Selmaj has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.
No disclosure on file
No disclosure on file
No disclosure on file
Daniel Press, MD (Beth Israel Deaconess Medical Center) Dr. Press has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for CND Life Sciences. Dr. Press has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Burke Neuroscience Board. The institution of Dr. Press has received research support from NIH. The institution of Dr. Press has received research support from Biogen. The institution of Dr. Press has received research support from Janssen. Dr. Press has received publishing royalties from a publication relating to health care. Dr. Press has received personal compensation in the range of $500-$4,999 for serving as a Advisory Panel Member with FDA.
No disclosure on file
No disclosure on file