Abstract Details

Title Postural Orthostatic Tachycardia Syndrome Associated with Multiple Sclerosis

Topic Autonomic Disorders

Presentation(s) P03 - (-)

Poster/Presentation
Number 041

Objective

Background BACKGROUND: Most cases of POTS are idiopathic, and secondary form of POTS occurs in association with a variety of other medical illnesses. Although orthostatic dizziness has been commonly seen in MS patients there have been no studies demonstrating the occurrence of POTS in patients with MS.

Design/Methods DESIGN/METHODS: We analyzed data gathered from 293 (112 with MS and 181 without MS) patients who underwent the head-up tilt table test protocol. If POTS was identified the head-up tilt table test was repeated and supine and standing serum epinephrine and norepinephrine were determined.

Results RESULTS: POTS was identified in 39 patients: 21 (19%) in the MS group comparing to 18 (10%) in the non MS group (p=0.035). There was no difference between groups in the occurrence of POTS associated syncope (p=0.52). There was no difference between groups in the epinephrine or norepinephrine in supine and standing positions. While both standing epinephrine and norepinephrine levels were significantly higher comparing to laying levels in the non MS group, only standing norepinephrine levels were significantly higher in the MS group.

Conclusions CONCLUSIONS: The results of this study suggest that POTS is associated with MS.

Authors/Disclosures
Ivan Adamec (University Hospital Center Zagreb) PRESENTER	Ivan Adamec has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Ivan Adamec has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Ivan Adamec has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Ivan Adamec has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Ivan Adamec has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Ivan Adamec has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Ivan Adamec has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sandoz. Ivan Adamec has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Zentiva. Ivan Adamec has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Jadran Galenski laboratorij. Ivan Adamec has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Phoenix farmacija.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Ivo Bach, MD	Dr. Bach has nothing to disclose.
	No disclosure on file
Mario Habek, MD (University of Zagreb, School of Medicine)	Dr. Habek has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Habek has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck . Dr. Habek has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Habek has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Astra Zeneca. Dr. Habek has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Habek has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Habek has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Habek has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Habek has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.
Douglas L. Arnold, MD, FAAN (Montreal Neurological Institute, McGill Univ)	Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for BMS. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Frequency Therapeutics. Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Dr. Arnold has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. Dr. Arnold has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Shionogi. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Xfacto communications. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biohaven. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Find therapeutics. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GSK. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Idorsia. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Kiniksa. Dr. Arnold has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Clario.

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