Abstract Details

Title Outcomes of Patients with Transverse Myelitis Who Developed Venous Thromboembolism While Hospitalized

Topic MS and Related Diseases

Presentation(s) P02 - (-)

Poster/Presentation
Number 104

Objective

Background BACKGROUND: Venous thromboembolism (VTE) is a serious complication encountered in hospitalized patients. Transverse myelitis routinely requires prolonged hospitalization for diagnostic investigations and treatment. These patients are at risk for developing VTE, however, the outcomes and VTE complications in patients with TM have not been reported.

Design/Methods DESIGN/METHODS: We analyzed the data from the Nationwide Inpatient Sample (NIS 2006-2010) for all patients possessing a diagnosis of TM with and without VTE complications such as DVT and PE. Patients were identified using the ICD 9 CM codes. Baseline characteristics, in hospital complications such as pneumonia and myocardial infarction, hospital charges, and discharge outcomes (mortality, minimal disability, and moderate to severe disability) were compared between the groups.

Results RESULTS: Of the 3760 patients admitted with transverse myelitis, 45 had DVT and PE (1.2%). Baseline characteristics analyzed were age, sex, race, and medical co-morbidities such as; hypertension, diabetes mellitus, congestive heart failure, chronic lung disease, and tobacco dependence. The percentage of females was higher in the DVT and PE group (88% vs 59%) (p <0.04). The inpatient mortality rate was significantly higher in patients who suffered from a DVT and PE when compared to patients who did not (11% vs 0.5%) p <0.01. After adjusting for age, sex, and co-morbidities, the presence of DVT and PE was associated with higher rates of in-hospital mortality (odds ratio [OR], 21; 95% CI (2.2-2.7) p <0.008.

Conclusions CONCLUSIONS: To our knowledge, this is the first study which reports significantly higher mortality rates in patients with TM who develop DVT and PE while hospitalized within the United States. This data supports prompt initiation of VTE prophylaxis in patients hospitalized with TM.

Authors/Disclosures
Samuel J. Maiser, MD (Hennepin Healthcare) PRESENTER	Dr. Maiser has nothing to disclose.
	No disclosure on file
Pezhman Roohani, MD	No disclosure on file
Nauman Tariq, MD	Dr. Tariq has received personal compensation for serving as an employee of NC neurological society .
	No disclosure on file
	No disclosure on file

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