Abstract Details

Title T2 Lesion Load Influences Cognitive Impairment at the Early Phase of MS

Topic MS and Related Diseases

Presentation(s) P04 - (-)

Poster/Presentation
Number 110

Objective

Background BACKGROUND: Cognitive impairment is frequently observed in multiple sclerosis (MS), even at the early stage of the disease. However, the prospective evaluation of cognitive dysfunctions and their association with MRI measurements remain discussed.

Design/Methods DESIGN/METHODS: The study was carried out on 99 patients with CIS that were followed-up for at least three years in our centre. MRI was performed at baseline on a 1.5T scanner (Siemens) and baseline T2-lesion load was calculated for each patient. Brief Repeatable Battery of neuropsychological tests was performed at baseline and after 5 and 10 years. Statistical analysis included frequency analysis, Spearman's correlations and Kruskal-Wallis Test.

Results RESULTS: The studied cohort of 99 CIS patients (disease duration 5 months +6; 18M/ 8F; mean age at the onset 30.3±7.5 years; mean follow-up 7.7±2.4 years. The first attack was often clinically monofocal (94.7% of patients). Mean EDSS at baseline was 0.9±0.7. There was no significant correlation between baseline EDSS and baseline T2- lesion load (r=0.162, p=0.1). At baseline, T2-lesion load significantly correlated with the scores of immediate and delayed visual memory (SPARTT r=-0.24, p=0.02 and SPARTD r=-0.24, p=0.02) and also with the phonemic fluency test ("letter P" r=-0.21, p=0.03). At year 5, we found a significant correlation between baseline T2-lesion load and delayed verbal memory scores (SRDT r=-0.32, p=0.02). Phonemic fluency remained associated with baseline T2-lesion load (r=-0.27, p=0.05) at this time point. At year 10, there was no significant correlation between neuropsychological parameters and baseline brain lesion load.

Conclusions CONCLUSIONS: Our results indicate that baseline T2-brain lesion load moderately predicts neuropsychological test performances at 5 years but not at 10 years.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
Alexandre Joyeux	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Lydie Crespy	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Jean Philippe Ranjeva	No disclosure on file
Bertrand Audoin	No disclosure on file
Jean Pelletier, MD, PhD (Dpt of Neurology, CHU Timone)	Dr. Pelletier has nothing to disclose.

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