Abstract Details

Title Acute Basilar Artery Occlusion: Safety and Efficacy of Different Treatment Strategies and Predictors of Good Outcome

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P01 - (-)

Poster/Presentation
Number 228

Objective

Background BACKGROUND: Acute ischemic stroke caused by BAO is often associated with a severe and persistent neurological deficit and a high mortality rate. Various treatment concepts are being used.

Design/Methods DESIGN/METHODS: The set consisted of 52 consecutive acute ischemic stroke patients (37 males; mean age 64.4 +/-13.0 years) with radiologically confirmed BAO. Stroke severity at time of treatment was assessed as severe (coma, locked-in state, tetraplegia) or mild to moderate. 30-day and 90-day outcome was assessed using modified Rankin scale with good outcome defined as score 0-3. The following treatments were used: antithrombotic treatment (AT); intravenous thrombolysis (IVT); IVT with subsequent intraarterial therapy (IVT+IAT); intraarterial therapy alone (IAT). Other observed factors were baseline characteristics, stroke risk factors, neurological deficit at time of treatment, estimated time BAO-therapy initiation, recanalization rate, post-treatment imaging findings, pre-event AT.

Results RESULTS: AT was used in 8, IVT in 14, IVT+IAT in 13, IAT in 17 patients. Good outcome was found in 1 (12.5 %) of AT, 3 (21.4 %) of IVT, 7 (53.8 %) of IVT+IAT, 4 (23.5 %) of IAT patients (p=0.178). Logistic regression analysis identified presence of arterial hypertension (OR=0.055, 95% CI: 0.004-0.851; p=0.038) and presence of severe stroke (OR=0.072, 95% CI: 0.006-0.892; p=0.040) as significant independent negative predictors of good outcome.

Conclusions CONCLUSIONS: In the presented study, an apparent trend for better outcome was observed in the IVT+IAT group. Presence of arterial hypertension and severe stroke were identified as independent negative predictors of good outcome.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
David Skoloudik, MD, PhD (University Hospital Ostrava)	No disclosure on file
Daniel Sanak	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
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	No disclosure on file
Michal Kral	No disclosure on file
	No disclosure on file
	No disclosure on file
Petr Hlustik, MD, PhD (Palacký University Olomouc)	The institution of Prof. Hlustik has received research support from Czech Health Research Council (AZV CR).
	No disclosure on file
	No disclosure on file
Petr Kanovsky, PhD	Dr. Kanovsky has nothing to disclose.

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