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Abstract Details

Diabetes Is Associated with Global and Regional Hypometabolism among Elderly Persons: The Mayo Clinic Study of Aging
Aging and Dementia
P07 - (-)
137
BACKGROUND: Type 2 diabetes is associated with brain atrophy, mild cognitive impairment, Alzheimer's disease (AD), and vascular dementia, possibly through vascular mechanisms. Some neuropathological studies have suggested greater plaque pathology in diabetics. Associations with in vivo markers of amyloid accumulation and hypometabolism are not established.
DESIGN/METHODS: We studied a population-based cohort of Olmsted County, MN residents across diagnostic categories (cognitively normal, mild cognitive impairment, dementia). PET images were acquired using a PET/CT scanner. FDG-PET images were obtained 1 hour after the PIB scan; diabetic subjects had normal glucose levels. MRI was performed at 3T with a 3D-MPRAGE sequence. Global and region of interest measures were obtained. Diabetes was determined using the Rochester Epidemiology Project medical records-linkage system.
RESULTS: Among 760 participants (median age 79 years), FDG ratio was lower in diabetics (n=160) than in non-diabetics (n = 601) for global FDG (1.575 vs. 1.620; p = 0.003), and in posterior cingulate/precuneus (1.752 vs. 1.812, p < 0.001), parietal (1.748 vs. 1.819, p = 0.002), temporal (1.488 vs. 1.519, p = 0.011), and prefrontal (1.727 vs. 1.785, p < 0.002) regions. However, the global PIB ratio did not differ in diabetics vs. non-diabetics (1.40 vs. 1.39; p = 0.43).
CONCLUSIONS: Diabetes was associated with lower FDG ratios globally and in regions that are among those thought to be key in AD. Our findings suggest that diabetes has a non-vascular role in the pathogenesis of AD.
Authors/Disclosures
Rosebud O. Roberts, MD (Mayo Clinic)
PRESENTER 		No disclosure on file
Michelle M. Mielke, PhD (Wake Forest University School of Medicine) Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for LabCorp. Dr. Mielke has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Siemens Healthineers. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sunbird Bio. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Mielke has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Roche. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novo Nordisk.
No disclosure on file
No disclosure on file
David S. Knopman, MD, FAAN (Mayo Clinic) Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. The institution of Dr. Knopman has received research support from NIH.
Barry S. Oken, MD, PhD, FAAN (Oregon Health & Science Univ.) Dr. Oken has nothing to disclose.
No disclosure on file
Yonas E. Geda, MD (Barrow Neurological Institute) The institution of Dr. Geda has received research support from NIH.
Bradley F. Boeve, MD, FAAN (Mayo Clinic) Dr. Boeve has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Rainwater Charitable Foundation. The institution of Dr. Boeve has received research support from Alector. The institution of Dr. Boeve has received research support from EIP Pharma. The institution of Dr. Boeve has received research support from Transposon. The institution of Dr. Boeve has received research support from Cognition Therapeutics. Dr. Boeve has received publishing royalties from a publication relating to health care.
Kejal Kantarci, MD (Mayo Clinic) The institution of Dr. Kantarci has received research support from Eli Lilly. The institution of Dr. Kantarci has received research support from NIH. The institution of Dr. Kantarci has received research support from ADDF. The institution of Dr. Kantarci has received research support from Eisai. The institution of Dr. Kantarci has received research support from BioArctic.
Walter A. Rocca, MD, MPH The institution of Dr. Rocca has received research support from National Institute on Aging - NIH. The institution of Dr. Rocca has received research support from National Heart, Lung, and Blood Institute - NIH.
Clifford R. Jack, Jr., MD (Mayo Clinic) The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic.
Ronald C. Petersen, MD, PhD, FAAN (Mayo Clinic) Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly and Co.. Dr. Petersen has received personal compensation in the range of $0-$499 for serving as a Consultant for Eisai, Inc.. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novo Nordisk. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has a non-compensated relationship as a Board of Directors with American Brain Foundation that is relevant to AAN interests or activities.
Val J. Lowe, MD (Mayo Clinic) Dr. Lowe has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AVID Radiopharmaceutical. Dr. Lowe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai Inc. The institution of Dr. Lowe has received research support from AVID Radiopharmaceuticals.