Abstract Details

Title Serial Structural Magnetic Resonance Imaging in Corticobasal Syndrome

Topic Movement Disorders

Presentation(s) P04 - (-)

Poster/Presentation
Number 164

Objective

Background BACKGROUND: Corticobasal degeneration syndrome (CBS) is a neurodegenerative disorder characterized by progressive cortical and extrapyramidal dysfunction. The diagnosis remains challenging with variable findings on pathology. Biomarkers to aid diagnosis remain elusive in all Parkinsonian disorders, although changes in brain structure assessed by MRI may improve diagnostic accuracy. Here we report on morphometric changes in a patient with CBS who underwent serial MRI.

Design/Methods DESIGN/METHODS: 3D T1-weighted MRI (3T Siemens Trio) was performed in a 68-year old right-handed man diagnosed with CBS twice (4/2010 and 12/2012). We used automated segmentation and parcellation software (FreeSurfer) to quantify cortical and subcortical thickness. We report on the brain regions showing greater than 15% cortical thickness change over this time period.

Results RESULTS: Widespread atrophy was noted in: R superior temporal gyrus (31.6%), R anterior transverse temporal gyrus(30.3%), R transverse temporal gyrus (27.9%), R lateral occipito-temporal gyrus, R anterior transverse collateral sulcus (18.1%), R fusiform gyrus (18%), L posterior-ventral cingulate gyrus (17.7%), R superior temporal gyrus (17.4%), L postcentral gyrus (16.8%), L lateral occipito-temporal sulcus (15.9%), L anterior cingulate (15.9%), R superior temporal gyrus (15.7%), L planum polar of the superior temporal gyrus (15.4%), R anterior occipital sulcus and preoccipital notch (15.4%). Two regions showed an increase in cortical thickness: L posterior transverse collateral sulcus (13.1%) and R superior occipital gyrus (10.3%).

Conclusions CONCLUSIONS: Expected reductions in cortical thickness involving asymmetric atrophy (R>L) of perirolandic and paracentral cortices were identified in our patient with CBS. We also found additional brain regions affected that are not known to be involved in this disorder. Serial structural MRI may represent a method by which diagnosis can be ascertained with more certainty and lead to a better understanding of pathophysiology.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Fatta B. Nahab, MD, FAAN (UCSD)	Dr. Nahab has received personal compensation for serving as an employee of Neuron23. Dr. Nahab has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Encora. Dr. Nahab has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for ActualSignal. Dr. Nahab has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Attune Neurosciences, Inc.. Dr. Nahab has stock in Biogen. Dr. Nahab has received personal compensation in the range of $500-$4,999 for serving as a DSMB Member with NIH.
David H. Margolin, MD, PhD (Genzyme Corporation)	Dr. Margolin has received personal compensation for serving as an employee of uniQure, Inc.. Dr. Margolin has stock in Cerevance, Inc. Dr. Margolin has stock in Datacubed Health. Dr. Margolin has stock in uniQure, Inc.. Dr. Margolin has received intellectual property interests from a discovery or technology relating to health care.

��ɫ��

��ɫ��