Abstract Details

Title Spatio-Temporal Characterization of beta and Higher Frequencies in Intra-Operative STN LFPs from PD Patients

Topic Movement Disorders

Presentation(s) P04 - (-)

Poster/Presentation
Number 178

Objective

Background BACKGROUND: Increased power in the low frequency bands of the local field potentials (LFPs) recorded from STN is considered as a potential physiomarker of the symptomatic state in Parkinson's disease (PD). Such physiomarkers can be used to improve the current therapies and reduce patient and physician burden via guided targeting, semi-automated contact selection and guided programming.

Design/Methods DESIGN/METHODS: LFP data were collected intra-operatively at sequential depths and times using DBS macroelectrodes from 31 patients (61 hemispheres) at rest during lead implantation surgery for STN DBS for PD.

Results RESULTS: We found at least one beta band peak in each hemisphere. The mean RMS amplitude of the peak power was 2.33uV +/- 1.8uV. We could also identify a specific recording site that exhibited significantly higher beta band power than adjacent depths. A bimodal distribution was observed for the frequencies of the peak beta power. Two other frequency bands were identified in a subset of patients. First, a peak was observed in the gamma band (60-90 Hz) in 21 patients (29 hemispheres). The contacts that exhibited the highest gamma power were often co-localized with the contacts with the highest beta power (r= 0.87; p<0.01). Second, in the data from 7 patients where higher frequencies were recorded, focal or broad peaks were also observed (130-400 Hz; 7/7 patients; 12/14 hemispheres). The spatial spread of observed peaks in the beta band was significantly greater (mean 9.2mm, p<0.01), than the gamma (3.1mm) and the high frequency bands (2.2mm).

Conclusions CONCLUSIONS: These results provide support for the potential usefulness of the beta band power as a marker for guiding DBS lead placement intra-operatively. In addition, our results suggest that increased power in the gamma band and higher frequencies often coexist with the beta band.

Authors/Disclosures
Rahul Gupta PRESENTER	No disclosure on file
	No disclosure on file
Ludwig Kappos, MD, FAAN (RC2NB, University Hospital Basel)	Dr. Kappos has nothing to disclose.

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