Abstract Details

Title Antibodies Against Gangliosides in the Serum of Patients Suffering from Multiple Sclerosis Compared with Healthy Individuals

Topic MS and Related Diseases

Presentation(s) P03 - (-)

Poster/Presentation
Number 243

Objective

Background BACKGROUND: Several studies have found increased anti-ganglioside antibody levels in the sera of MS patients connected with the chronic inflammation, the demyelination and the axonal injury.

Design/Methods DESIGN/METHODS: We examined the sera of 56 patients suffering from definite multiple sclerosis (MS) and 44 healthy individuals using ELISA techniques, for investigating the probable correlation between IgM antibodies against GM1, GD1b and GQ1b gangliosides and clinical parameters of multiple sclerosis.

Results RESULTS: Increased levels of anti-GM1 and anti-GD1b IgM antibodies in 70% and 57% of MS patients respectively were revealed while only 29% of MS patients demonstrated increased anti-GQ1b values. None of the healthy controls demonstrated positive anti-ganglioside titres. There wasn't found statistically significant correlation between serum anti-ganglioside antibodies and the type of MS, the disability, the duration of the disease or the kind of treatment (p>0.05). However, a probable correlation between anti-GD1b and anti-GM1 IgM levels with the progression of the disease was indicated. The present research also demonstrated a positive correlation between the duration of the disease and the disability. Patients with a duration of MS more than fourteen years showed the highest, but only moderate, disability (Expanded Disability Status Scale scores: 5.0-7.0) (p=0.001).

Conclusions CONCLUSIONS: Our results are indicative of a significant role of anti-GM1 and anti-GD1b IgM antibodies in MS. Further investigation should be established in order to provide insights on the potential autoantigenic role and the pattern of serum antibody reactivity to gangliosides in multiple sclerosis.

Authors/Disclosures
Effrosyni Koutsouraki (University General Hospital Ahepa) PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file

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