Abstract Details

Title Increased Risk of Intensive Care Unit Admission in Multiple Sclerosis

Topic MS and Related Diseases

Presentation(s) P03 - (-)

Poster/Presentation
Number 205

Objective

Background BACKGROUND: Care in intensive care units (ICU) is costly, and consumes a disproportionate share of medical costs. Little is known about the risk of ICU admission in persons with multiple sclerosis (MS).

Design/Methods DESIGN/METHODS: Using provincial administrative data we identified all persons with MS and an age, sex and geographically-matched general population cohort. For 2000-2010, we estimated the annual incidence and the 10-year cumulative incidence of ICU admission among prevalent cases of MS. Also, we estimated the incidence of ICU admission among a cohort with incident MS using Cox proportional hazards models adjusted for age at diagnosis, sex, comorbidity and socioeconomic status.

Results RESULTS: From 2000-2010, the age and sex-standardized annual incidence of ICU admission ranged from 0.51% to 1.07% in persons with MS and 0.36-0.60% in the general population. The 10-year average annual incidence rates were 0.80% in the MS and 0.45% in the general populations. The crude 10-year cumulative incidence of ICU admission was 6.03% in MS and 3.45% in the matched cohort (incidence rate ratio [IRR] 1.53). When compared to the general population, the incidence of ICU admission was increased at all ages, but the relative risk was higher among persons aged 18-39 (IRR 3.67) than among persons aged 40-59 (IRR 1.97) and than among persons aged ?60 years (IRR 1.38). When comparing incident cases of MS to the general population, the risk of ICU admission in a multivariable Cox model was increased (hazard ratio [HR] 1.45; 95% CI: 1.19-1.75).

Conclusions CONCLUSIONS: The risk of ICU admission is relatively high among persons with MS, particularly in younger MS patients. Given the recognized adverse consequences of critical illness in the general population, future studies should determine if there are modifiable risk factors for ICU admission.

Authors/Disclosures
Ruth-Ann Marrie, MD, PhD (University of Manitoba) PRESENTER	The institution of Dr. Marrie has received research support from CIHR. The institution of Dr. Marrie has received research support from MS Canada. The institution of Dr. Marrie has received research support from National MS Society. The institution of Dr. Marrie has received research support from Crohn's and Colitis Canada. The institution of Dr. Marrie has received research support from US Department of Defense. The institution of Dr. Marrie has received research support from The Arthritis Society. The institution of Dr. Marrie has received research support from CMSC.
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