好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Deep Brain Stimulation May Improve Quality of Life without Increasing Caregiver Burden
Movement Disorders
P04 - (-)
177
BACKGROUND: Evidence of DBS efficacy, tolerability and its positive impact on quality of life (QOL) has been reported by several studies. The impact of DBS on the caregiver has not, however, been well studied.
DESIGN/METHODS: A cross-sectional retrospective study utilizing the National Parkinson Foundation Quality Improvement Initiative clinical study was conducted. A group of 275 patients who had undergone deep brain stimulation for Parkinson's disease were extracted from 2,916 subjects who were included in this database. The data were compared to an age, sex, and disease severity matched control group. A secondary analysis was then performed on two more control groups that were matched to account for presence or absence of motor fluctuations. The multidimensional caregiver strain index and Parkinson's disease quality-of-life questionnaire 39 summary index were compared.
RESULTS: The multidimensional caregiver strain index did not differ between the deep brain stimulation group (16.9卤11.8) and a matched non deep brain stimulation group (16.1卤17.6, P=.618). The quality-of-life index was, however, significantly better in the deep brain stimulation group (28.9卤15.6) than in the non deep brain stimulation group (32.3卤17.6, P=.034). A secondary analysis revealed that the total caregiver strain score was lower in the no motor fluctuation control group than the other two groups (p<.05). Regression analyses revealed significant relationships between the quality-of-life index and caregiver strain index total scores (p<.001), between caregiver strain index total score and age at surgery (p=.027) and also between the interval since surgery (p=.048).
CONCLUSIONS: Deep brain stimulation may improve quality-of-life without significantly increasing caregiver burden. Motor fluctuations are contributors to caregiver strain and quality-of-life.
Authors/Disclosures
Genko Oyama, MD, PhD, FAAN (Saitama Medical University)
PRESENTER 		Dr. Oyama has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medtronic. Dr. Oyama has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Boston Scientific. Dr. Oyama has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Otsuka Pharmaceutical Co. Ltd.. Dr. Oyama has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sumitomo Dainippon Pharma Co. Ltd.. Dr. Oyama has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eisai Co., Ltd.. Dr. Oyama has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Takeda Pharmaceutical Company LTD.. Dr. Oyama has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Kyowa Hakko Kirin Co. Ltd.. Dr. Oyama has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AbbVie, Inc. The institution of Dr. Oyama has received research support from AbbVie, Inc. The institution of Dr. Oyama has received research support from GLORY LTD. The institution of Dr. Oyama has received research support from Kirin Company LTD. The institution of Dr. Oyama has received research support from Mitsubishi UFJ Lease & Finance Company LTD. The institution of Dr. Oyama has received research support from Sunwels Co., Ltd. The institution of Dr. Oyama has received research support from Ohara Pharmaceutical Co.,Ltd.. The institution of Dr. Oyama has received research support from PARKINSON Laboratories Co., Ltd..
Michael S. Okun, MD, FAAN (University of Florida) Dr. Okun has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NIH. Dr. Okun has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Parkinson's Foundation. Dr. Okun has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. Dr. Okun has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for NEJM Journal Watch. The institution of Dr. Okun has received research support from NIH. The institution of Dr. Okun has received research support from Parkinson's Foundation. The institution of Dr. Okun has received research support from Tourette Association of America. The institution of Dr. Okun has received research support from Michael J Fox. Dr. Okun has received publishing royalties from a publication relating to health care.
No disclosure on file
Peter T. Schmidt, PhD No disclosure on file
Alexander I. Troster, PhD (Barrow Neurological Institute) Dr. Troster has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medtronic. Dr. Troster has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Takeda. Dr. Troster has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sage Therapeutics. Dr. Troster has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Cambridge University Press/International Neuropsychological Society. The institution of Dr. Troster has received research support from Barrow Neurological Foundation. Dr. Troster has received publishing royalties from a publication relating to health care.
John G. Nutt, MD, FAAN (Oregon Health & Science University) No disclosure on file
No disclosure on file
Kelly D. Foote, MD Kelly D. Foote, MD has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Axio/Neurocrine Biosciences.
Florian Then Bergh, MD (University of Leipzig, Klinik u. Poliklinik fuer Neurologie) Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Horizon. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Actelion. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Alexion. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Genzyme. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Fresenius. Dr. Then Bergh has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Merck. Dr. Then Bergh has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Takeda. The institution of Dr. Then Bergh has received research support from Actelion. The institution of Dr. Then Bergh has received research support from Novartis. The institution of Dr. Then Bergh has received research support from DFG (German Science Fund). The institution of Dr. Then Bergh has received research support from Fresenius. The institution of Dr. Then Bergh has received research support from Diamed. Dr. Then Bergh has received personal compensation in the range of $10,000-$49,999 for serving as a Member of the Institutional Ethics Board with University of Leipzig, Medical Faculty.
Nobutaka Hattori, MD, PhD, FANA (Juntendo University School of Medicine) Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving as a Consultant for PARKINSON Laboratories Co., Ltd. Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Kyowa Kirin Co., Ltd. . Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for TEIJIN PHARMA LIMITED.. Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sumitomo Dainippon Pharma Co., Ltd.. Prof. Hattori has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ono Pharmaceutical Co., Ltd.. Prof. Hattori has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Kyowa Kirin Co., Ltd. . Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AbbVie GK. Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eisai Co., Ltd. . Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Otsuka Holdings Co.,Ltd.. Prof. Hattori has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Ono Pharmaceutical Co., Ltd.. Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eisai Co., Ltd. . Prof. Hattori has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sumitomo Dainippon Pharma Co., Ltd.. Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Takeda Pharma Co., Ltd.. Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis Pharma K.K.. Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for DAIICHI SANKYO Co., Ltd.. Prof. Hattori has received stock or an ownership interest from PARKINSON Laboratories Co., Ltd. The institution of Prof. Hattori has received research support from Japan Society for the Promotion of Science (JSPS). The institution of Prof. Hattori has received research support from Japan Agency for Medical Research and Development (AMED). The institution of Prof. Hattori has received research support from Japan Science and Technology Agency, Health Labour Sciences Research Grant. The institution of Prof. Hattori has received research support from Japan Science and Technology Agency (JST). The institution of Prof. Hattori has received research support from Kyowa Kirin Co.,Ltd.. The institution of Prof. Hattori has received research support from Medtronic, Inc.. The institution of Prof. Hattori has received research support from Boston Scientific Corporation. The institution of Prof. Hattori has received research support from TEIJIN PHARMA LIMITED.. The institution of Prof. Hattori has received research support from AbbVie GK. The institution of Prof. Hattori has received research support from FP Pharmaceutical Corporation. The institution of Prof. Hattori has received research support from Dai-Nippon Sumitomo Pharma Co.,Ltd. The institution of Prof. Hattori has received research support from Nihon Medi-physics Co.,Ltd.,. The institution of Prof. Hattori has received research support from Eisai Co.,Ltd. . The institution of Prof. Hattori has received research support from Kirin Holdings Company, Limited. The institution of Prof. Hattori has received research support from Mitsubishi UFJ Trust and Banking Corporation. The institution of Prof. Hattori has received research support from GLORY LTD.. The institution of Prof. Hattori has received research support from Nippon Life Insurance Company. The institution of Prof. Hattori has received research support from Otsuka Pharmaceutical, Co.,Ltd. The institution of Prof. Hattori has received research support from AbbVie GK,. The institution of Prof. Hattori has received research support from Meiji Seika Pharma Co., Ltd.. The institution of Prof. Hattori has received research support from Ono Pharmaceutical Co., Ltd.. The institution of Prof. Hattori has received research support from FUJIFILM Wako Pure Chemical Corporation. The institution of Prof. Hattori has received research support from Sunwels,Inc.. The institution of Prof. Hattori has received research support from OHARA Pharmaceutical Co.,Ltd.. The institution of Prof. Hattori has received research support from PARKINSON Laboratories Co., Ltd.. The institution of Prof. Hattori has received research support from Ono Pharmaceutical Co., Ltd.. Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving as a Team Leader with RIKEN Center for Brain Science. Prof. Hattori has received personal compensation in the range of $500-$4,999 for serving as a Program officer with AMED: Japan Agency for Medical Research and Development.
Irene Malaty, MD, FAAN (University of Florida) Dr. Malaty has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbvie. Dr. Malaty has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Aevum. The institution of Dr. Malaty has received research support from Abbvie. The institution of Dr. Malaty has received research support from Revance. The institution of Dr. Malaty has received research support from Parkinson Foundation. The institution of Dr. Malaty has received research support from SAGE. The institution of Dr. Malaty has received research support from Emalex. The institution of Dr. Malaty has received research support from Acadia. Dr. Malaty has received publishing royalties from a publication relating to health care. Dr. Malaty has received personal compensation in the range of $500-$4,999 for serving as a Speaker & Center of Excellence Director with Parkinson Foundation. Dr. Malaty has a non-compensated relationship as a MAB member & Center of Excellence Directory with Tourette Association of America that is relevant to AAN interests or activities.