Abstract Details

Title The Relationship between Cognitive Testing and Gait and Balance Measures in Parkinson's Disease

Topic Movement Disorders

Presentation(s) P04 - (-)

Poster/Presentation
Number 169

Objective

Background BACKGROUND: It is known that cognitive function, especially executive function and attention play a role in gait and falls. However, it is not known how cognitive impairments relate to objective measures of balance and gait in neurological disorders such as PD. The purpose of this study was to better delineate this relationship.

Design/Methods DESIGN/METHODS: This is a cross sectional study using baseline data from a vitamin D intervention study. Nineteen participants with a mean PD duration of 9.5 years (SD+5.9) underwent cognitive, gait, and balance testing in the "on" state. All testing was completed within a one-month time window. Pearson correlations were used to correlate gait and balance measures and cognitive test performance. Gait was measured with an instrumented Timed Up and Go (iTUG) test from APDM and balance with a Sensory Organization Test (SOT) and Motor Control Test (MCT) to backwards and forwards perturbations from Neurocom Equitest. Cognitive measures included tests of global function (MOCA), memory (WMS-III Logical Memory), executive (trails A & B, Stroop, WAIS-III letter-number sequencing, digit symbol), visual spatial (JoLo), attention (Stroop, WAIS-R digit span forwards and backwards), and language (Boston naming, verbal fluency f's, animals, vegetables).

Results RESULTS: The most consistent correlations were between measures of executive function and gait and balance. Trails A correlated with stride velocity (p=0.01); Trails B with equilibrium score in condition 5 of the SOT (p=<0.01); and Stroop with turn duration (p=0.02), equilibrium score condition 5 of the SOT (p=0.04) and latency to forward perturbations in the MCT (p=0.03). The most correlations were found with the Stroop test, which measures both attention and executive function.

Conclusions CONCLUSIONS: Our data supports the relationship between objective gait and balance measures and cognitive function, specifically executive function in patients with PD.

Authors/Disclosures
Amie L. Hiller, MD PRESENTER	The institution of Dr. Hiller has received research support from Admas Pharmaceuticals.
	No disclosure on file
	No disclosure on file
Fay B. Horak, PhD (OHSU)	No disclosure on file
	No disclosure on file

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