Abstract Details

Title Botulinum Toxin Treatments for Sialorrhea Can Reduce Aspiration Related Hospitalizations

Topic Autonomic Disorders

Presentation(s) P03 - (-)

Poster/Presentation
Number 027

Objective

Background BACKGROUND: Sialorrhea is a common symptom in many primary neurologic disorders which can affect the health of patients. Injection of botulinum toxin into the submandibular and parotid glands has been shown to significantly reduce saliva production in multiple studies for diverse study populations.

Design/Methods DESIGN/METHODS: Our study is a retrospective review of 4 patients with clinically significant sialorrhea who were referred for botulinum toxin treatment due to recurrent aspiration pneumonia. Two patients received botulinum toxin A and two patients received botulinum toxin B. Injections occurred every 3-4 months. Primary outcome was hospitalization due to aspiration pneumonia, pneumonitis or respiratory symptoms.

Results RESULTS: Sialorrhea was subjectively reported to be improved for all patients. 2 patients' outside medical records were available for analysis. Both patients had been treated with botulinum toxin A. Prior to treatment with toxin, patient 1 was hospitalized for respiratory symptoms an average of 17.8 days/year and patient 2 was hospitalized 25.6 days/year. Following treatment patient 1 was hospitalized 0.8 days/year and patient 2 was hospitalized 1.6 days/year. None of the patients reported adverse responses including dysphagia, respiratory insufficiency, or dry mouth.

Conclusions CONCLUSIONS: Botulinum toxin is a highly efficacious method for prevention of aspiration pneumonia due to sialorrhea with few adverse effects. Botulinum toxin therapy can both improve quality of life for patients and limit hospitalization associated costs.

Authors/Disclosures
Daniel Lai, MD PRESENTER	No disclosure on file
Jaime R. Lopez, MD (Stanford University School of Medicine)	An immediate family member of Dr. Lopez has received personal compensation for serving as an employee of AbbVie. Dr. Lopez has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Clinical Neurophysiology. Dr. Lopez has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for medical-legal consulting.
	No disclosure on file

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