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Abstract Details

Autonomic Evaluation in Cardiovascular Patients Infected by Virus Hepatitis C: A Series of 35 Patients
Autonomic Disorders
P03 - (-)
022
BACKGROUND: Infection with the hepatitis C virus (HCV) affects approximately 170 million people worldwide and some changes due to virus in the nervous system. In Brazil, it is estimated that this number of 1.5 million people. The state of Acre is the site of highest incidence of HCV-infected individuals, about 22/100.000 inhabitants. This number of patients with hepatitis C, is four times the amount of HIV-infected patients. Among peripheral nervous system (PNS) manifestations related chronic inflammatory polyneuropathy (CIDP) and the predominantly sensory polyneuropathy. PNS vasculitis changes found in association with HCV infection. Although there are few reported cases of dysautonomia C virus infection and hepatitis.
DESIGN/METHODS: We evaluated the cardiovascular autonomic function in 35 patients infected with hepatitis C virus and sensory polyneuropathy. The mean age was 54.9 years and 16 patients were male (44%) and 19 female (66%). We performed four tests that measure cardiovascular autonomic indirectly function cardiovascular efferent sympathetic or parasympathetic. Tests included: respiratory sinus arrhythmia, passive tilt testing, static testing effort and Valsalva maneuver.
RESULTS: Among the cardiovascular autonomic tests we found in 11% change in respiratory sinus arrhythmia, 14% in passive tilt, 20% in static and 34% effort in the Valsalva maneuver.
CONCLUSIONS: The presence of predominantly sensory polyneuropathy in patients infected with hepatitis C virus may be associated with impaired autonomic cardiovascular. Both cardiovascular autonomic pathways are affected. However the cardiovascular efferent sympathetic branch is the most affected in this series.
Authors/Disclosures
Bruno Coutinho, MD (InNeuro)
PRESENTER 		No disclosure on file
Osvaldo J. Nascimento, MD, PhD, FAAN (Fluminense Federal University) Dr. Nascimento has nothing to disclose.
David E. Blum, MD Dr. Blum has received personal compensation for serving as an employee of Neurona Therapeutics. Dr. Blum has stock in Neurona Therapeutics.