Abstract Details

Title Cyclophosphamide Does Not Affect Fertility in Young Multiple Sclerosis Patients

Topic MS and Related Diseases

Presentation(s) P02 - (-)

Poster/Presentation
Number 133

Objective

Background BACKGROUND: It is well known that Cyc can induce ovarian failure and infertility and can have teratogenic effect on the foetus. There have been few case report of successful pregnancy after Cyc treatment in women with autoimmune disease or malignancies, but there is no available information about fertility and pregnancy outcomes in MS patients previously exposed to Cyc administration.

Design/Methods DESIGN/METHODS: We reviewed retrospectively the medical records of MS patients in childbearing age consecutively referring to the MS center of Catania, who had been treated with intra venous (i.v.) Cyc. We found 11 patients who experienced a pregnancy after having received Cyc treatment.

Results RESULTS: Out of the 11 patients, two are still pregnant, one underwent a voluntary abortion, the remaining 8 had a successful delivery. The mean age was 26±1.9 years at the beginning of Cyc treatment and 30.8±1.9 years at the time of conception. Women received an average cumulative doses of Cyc of 16.1±2.4 g. The time lapse between the last administration of Cyc and conception was 3.27±1.9 years. Four women had a pre-term delivery. One patient experienced a spontaneous abortion before the successful pregnancy. One child was small for gestational age. The average baby body weight was 2964.4±221.0 g. All babies achieved the developmental milestones (walking and speaking) within one year.

Conclusions CONCLUSIONS: We describe 11 pregnancies in women with MS previously exposed to Cyc treatment: eight were successful, two are still on going and one experienced a voluntary abortion. Our findings could encourage clinicians to use Cyc for short period in selected cases of young MS patients of childbearing age.

Authors/Disclosures
Francesco Patti, MD PRESENTER	Dr. Patti has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. The institution of Dr. Patti has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Almirall. Dr. Patti has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Meyers. Dr. Patti has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Johnson and Johnson. The institution of Dr. Patti has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Merck. The institution of Dr. Patti has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. The institution of Dr. Patti has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. The institution of Dr. Patti has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sanofi. Dr. Patti has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Almirall, Bayer, Biogen, Bristol Meyers and Squibb Merck, Roche, Sanofi, TEVA. Dr. Patti has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for University of Catania and AISM/FISM, Fondazione Italiana Sclerosi Multipla. Dr. Patti has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Frontiers in Neurology.
Silvia Messina (AOU Policlinico Vittorio Emanuele)	No disclosure on file
Salvatore Lo Fermo	No disclosure on file
Emanuele D'Amico	Emanuele D'Amico has nothing to disclose.
	No disclosure on file
Clara Chisari, MD	Clara Chisari, MD has nothing to disclose.
	No disclosure on file
Federica Masuzzo	No disclosure on file
Mario Zappia, MD (Università Degli Studi Di Catania- Dept of Medical & Surgical Sciences)	No disclosure on file
Angelo Ghezzi, MD	No disclosure on file

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