Abstract Details

Title Brain Volume Changes May Predict Conversion in Radiologically Isolated Syndromes

Topic MS and Related Diseases

Presentation(s) P04 - (-)

Poster/Presentation
Number 132

Objective

Background BACKGROUND: MRI lesions suggestive of multiple sclerosis (MS) in the absence of a clinical scenario is a condition named ''radiologically isolated syndrome'' (RIS).

Design/Methods DESIGN/METHODS: A retrospective review of RIS cases with at least 1 year of follow up was performed. Demographic, MRI findings (brain volumes and brain and spinal cord lesion load) and oligoclonal bands (OB) in CSF were analyzed as potential predictors for clinical progression.

Results RESULTS: 12 subjects with RIS were included (mean follow up time 33.6 ± 12 months). 5 (42%) of them progressed clinically (3 to CIS, 2 to RRMS) over a mean time of 18 ± 5 months from the date of RIS identification. After adjusting for potential confounders, demographic, OB and lesion load in brain and spinal cord were not associated with progression of RIS. RIS subjects that progressed showed a decrease in white matter brain volume (0.9 x106 vs. 1.1x106, p=0.04), grey matter brain volume (0.5 x106 vs. 0.59x106, p=0.005) and total brain volume (1.51 x106 vs. 1.59x106 p=0.02) compared with RIS patients that did not.

Conclusions CONCLUSIONS: We observed a decrease in brain volumes of patients with RIS that progressed to CIS or MS. Brain atrophy would be a predictive factor for conversion in RIS if confirms by further studies.

Authors/Disclosures
Liliana B. Patrucco, MD (Hospital Italiano De Buenos Aires) PRESENTER	Dr. Patrucco has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Dr. Patrucco has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Patrucco has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Novartis. Dr. Patrucco has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Biogen.
	No disclosure on file
Giancarlo Comi, MD (University Vita-Salute)	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
	No disclosure on file
	No disclosure on file
Edgardo Cristiano, MD (Hospital Italiano De Buenos Aires)	Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Genzyme. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.

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