Abstract Details

Title Left Dominancy of EEG Abnormalities in Patients with Transient Global Amnesia

Topic Aging and Dementia

Presentation(s) P07 - (-)

Poster/Presentation
Number 138

Objective

Background BACKGROUND: Transient global amnesia (TGA) is a syndrome of unknown etiology. Electroencephalogram (EEG) abnormalities in patients with TGA were variably reported. We analyzed the frequency and significance of EEG abnormalities and characterized EEG findings in TGA patients.

Design/Methods DESIGN/METHODS: We collected EEGs of clinical TGA patients who visited the emergency room or outpatient clinic for 8 years and compared normal EEG group with abnormal EEG group.We retrospectively collected medical records of patients who had visited the emergency room or outpatient clinic in our hospital from 2003 to 2011 and been clinically diagnosed as TGA by Hodge & Warlow criteria.

Results RESULTS: EEG abnormalities were found in 35 (22.9%) patients out of 153 and epileptiform discharges out of them were found in 26 (74.3%). Spikes or sharp waves were detected in left side only (48.6%) or in both sides (25.7%) but there was no patient who had spikes or sharp waves in right side only. It took an average of 3.8±6.0 days from TGA attack to EEG recording, 2.9±4.6 days in the abnormal group and 4.0±6.3 days in the normal group. EEG was normalized in 12 patients and continuously abnormal in 11 out of 23 for one year. Six patients experienced normalized EEG within 3 months and 10 patients within 6 months.

Conclusions CONCLUSIONS: Epileptiform discharges in our cases were much higher than literature and normalized in the follow-up EEGs for one year. Left dominancy of EEG abnormalities was remarkable in patients with TGA. This is the largest consecutive EEG study performed in patients with TGA in one center.

Authors/Disclosures
PRESENTER	No disclosure on file
Emilia M. Gatto, MD, FAAN (INEBA)	Dr. Gatto has received personal compensation in the range of $0-$499 for serving as a Consultant for UCB. Dr. Gatto has received personal compensation in the range of $0-$499 for serving as a Consultant for Bago Argentina. Dr. Gatto has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bago. Dr. Gatto has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for UCB. Dr. Gatto has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Janssen. Dr. Gatto has received research support from Roche. The institution of Dr. Gatto has received research support from CHDI.
SangYun Kim, MD, PhD (Prof)	No disclosure on file
	No disclosure on file

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