Abstract Details

Title Age Effects on the Neural Basis of Self-Generation Verbal Learning

Topic Aging and Dementia

Presentation(s) P07 - (-)

Poster/Presentation
Number 130

Objective

Background BACKGROUND: Studies have documented increased cortical involvement for generate>read condition in the bilateral inferior/middle frontal gyri, anterior cingulate, caudate and bilateral temporo-parietal junction with better subsequent memory performance positively correlated with activation in the left superior temporal gyrus. The goal of the present study was to determine the age effects on the process of active learning in healthy adults spanning in age over 6 decades.

Design/Methods DESIGN/METHODS: 110 right-handed subjects (age 18-76; 47F) were scanned at 3T using a paired associates event-related fMRI task (Vannest et al., 2012). In this task, related word pairs were presented in "read" condition (subjects viewed both words and read the second word aloud), or "generate" condition (the second word was presented with only the first letter and the subject was required to generate the word). Thirty word-pairs were presented in each condition. After the fMRI scan, words that were read or generated were presented, each with two foils, in a forced-choice recognition task. FMRI data were processed using GLM implemented in CCHIPS.

Results RESULTS: During fMRI more words were correctly read (98.8%) than correctly generated (79.9%; t(109)=20.19, p<0.001). On the recognition post-test, more generated words were correctly recognized than read words (77.8% for generated words, 69.9% for read words; t(109)=7.28, p<0.001). Age was a predictor of post-test recognition performance, older adults tended to perform less accurately (r=-0.21, p<0.05). A number of frontal and parietal brain regions showed significant increases in activation with age for "generate" versus "read". The left insula showed significant decreases in activation with increasing age for subsequently remembered words versus subsequently forgotten ones.

Conclusions CONCLUSIONS: Widespread negative effects of aging on cortical correlates of verbal learning were observed with left insula playing a greater role in successful encoding in younger subjects.

Authors/Disclosures
Jerzy P. Szaflarski, MD, PhD, FAAN (University of Alabama At Birmingham) PRESENTER	Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB Pharma. Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for LivaNova Inc. Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for PureTech Health. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Gidley, Sarli & Marusak, LLP. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Law Firm. Dr. Szaflarski has stock in AdCel Biopharma, LLC. Dr. Szaflarski has stock in iFovea.
Jennifer Vannest (Cincinnati Childrens Hospital)	No disclosure on file
	No disclosure on file
Jane B. Allendorfer, PhD (U of Alabama At Birmingham, Neurology)	The institution of Dr. Allendorfer has received research support from National Institutes of Health. The institution of Dr. Allendorfer has received research support from Evelyn F. McKnight Brain Institute. The institution of Dr. Allendorfer has received research support from LivaNova, Inc. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Cleveland Clinic. Dr. Allendorfer has received personal compensation in the range of $0-$499 for serving as a Examiner with University of Auckland. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Speaker with International League Against Epilepsy. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Grant Reviewer with Department of Defense. Dr. Allendorfer has a non-compensated relationship as a Scientific Program Committee Member with American Epilepsy Society that is relevant to AAN interests or activities. Dr. Allendorfer has a non-compensated relationship as a Editorial Board Member with Epilepsy and Behavior Reports that is relevant to AAN interests or activities.
	No disclosure on file
Terrie Livingston, PharmD (EMD Serono)	Ms. Livingston has received personal compensation for serving as an employee of Octave Bioscience. Ms. Livingston has received personal compensation for serving as an employee of EMD Serono. Ms. Livingston has stock in Biogen. Ms. Livingston has stock in Octave Bioscience.
	No disclosure on file

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