好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Incidence of Dementia with Lewy Bodies and Parkinsonism with Dementia
Aging and Dementia
P03 - (-)
097
BACKGROUND: We investigated the incidence of Dementia with Lewy Bodies (DLB) among residents of Olmsted County, MN, and compared it to the incidence of Parkinsonism with Dementia (PDD).
DESIGN/METHODS: We used the medical records-linkage system of the Rochester Epidemiology Project to identify all persons who developed parkinsonism from 1991 through 2005 (15 years). A movement disorders specialist reviewed the complete medical records of each suspected patient to confirm the diagnosis.
RESULTS: Among 542 incident cases of parkinsonism, 64 had DLB and 46 had PDD. The incidence rate of DLB was 3.5 per 100,000 person-years overall, and it increased steeply with age. Similarly, the incidence of PDD was 2.5 overall, and also increased steeply with age. The incidence rate of DLB and PDD combined was 5.9. Patients with DLB were younger at onset of symptoms and had more documented hallucinations and cognitive fluctuations than patients with PDD. Men had a substantially higher incidence of DLB than women across the full age spectrum. The men to women difference in risk of DLB was more extreme than the difference in risk for Parkinson's disease, as previously reported from the same population. In particular, we observed an incidence of DLB of 4.8 in men and 2.2 in women as compared with 18.7 in men and 10.2 in women for PD. The pathology was consistent with the clinical diagnosis in 24 of 31 patients who underwent autopsy (77.4%).
CONCLUSIONS: The overall incidence rate of DLB is lower than the rate for Parkinson's disease. DLB risk not only increases steeply with age, but is markedly greater in men. The men to women difference may suggest different biologic mechanisms.
Authors/Disclosures
Rodolfo Savica, MD, PhD, FAAN (Mayo Clinic)
PRESENTER 		The institution of Dr. Savica has received research support from ACADIA Pharmaceuticals, Inc.
Brandon R. Grossardt, MS (Mayo Clinic College of Medicine) No disclosure on file
James H. Bower, MD, MSc, FAAN (Mayo Clinic) The institution of Dr. Bower has received research support from Abbvie.
Bradley F. Boeve, MD, FAAN (Mayo Clinic) Dr. Boeve has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Rainwater Charitable Foundation. The institution of Dr. Boeve has received research support from Alector. The institution of Dr. Boeve has received research support from EIP Pharma. The institution of Dr. Boeve has received research support from Transposon. The institution of Dr. Boeve has received research support from Cognition Therapeutics. Dr. Boeve has received publishing royalties from a publication relating to health care.
J. E. Ahlskog, MD, PhD (Mayo Clinic) Dr. Ahlskog has received publishing royalties from a publication relating to health care.
Walter A. Rocca, MD, MPH The institution of Dr. Rocca has received research support from National Institute on Aging - NIH. The institution of Dr. Rocca has received research support from National Heart, Lung, and Blood Institute - NIH.
Kelly D. Foote, MD Kelly D. Foote, MD has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Axio/Neurocrine Biosciences.