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Abstract Details

Are Problems Retrieving Proper Names a Harbinger of Disease in Older Adults?
Aging and Dementia
P07 - (-)
146
BACKGROUND: Retrieval of proper names is a common complaint of older patients and neurologists often question whether this symptom is an aspect of "normal aging" or a harbinger of incipient neurodegenerative disease.
DESIGN/METHODS: We studied 27 older subjects:17 CN (mean age 74.8 卤 6.4 years, MMSE = 29.4 卤 0.7) and 10 amnestic MCI (71.9 卤 8.8 years, MMSE = 27.7 卤 2.7) using a modified Face Name Associative Memory Exam (FNAME), which tested retrieval for 12 novel face-name-occupation pairs, and 12 famous face-name-occupation pairs. A subgroup (n=18) also underwent PiB-PET imaging. Using multiple linear regression analysis, we related FNAME to PiB retention (DVR, cerebellar reference) as a continuous variable in the precuneus, co-varying for age.
RESULTS: MCI subjects performed significantly worse on the retrieval of newly learned face-name pairs (p<0.006) but not face-occupation pairs (p=0.155) whereas MCI performed similarly to CN on the retrieval of famous face-name pairs (p= 0.33) and famous face-occupation pairs (p= 0.12). Within the PiB-PET subgroup, famous face-name retrieval demonstrated a negative relationship with increasing A? deposition in both CN (R2= 0.067) and MCI (R2= 0.237). Famous face-occupation performance showed a negative relationship with A? in MCI (R2 = 0.53) but not CN (R2 = 0.005).
CONCLUSIONS: These findings suggest that with increasing A? burden, retrieval of proper names is difficult across all individuals but further A?-related decrements in semantic knowledge, a clinically more worrisome symptom, tends to dissociate MCI from CN.
Authors/Disclosures
Sarah E. Wigman, BA (Brigham and Woman's Hospital)
PRESENTER 		No disclosure on file
Kathryn V. Papp, PhD (Brigham & Women's Hospital) No disclosure on file
No disclosure on file
No disclosure on file
Keith A. Johnson, MD (MGH) Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AC Immune. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Shionogi. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Prothena. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NervGen. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Oligomerix. Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AC Immune. The institution of Dr. Johnson has received research support from National Institute on Aging. The institution of an immediate family member of Dr. Johnson has received research support from Alzheimer's Association. The institution of an immediate family member of Dr. Johnson has received research support from Eli Lilly and Co. The institution of Dr. Johnson has received research support from Eisai. The institution of an immediate family member of Dr. Johnson has received research support from Eisai.
Reisa A. Sperling, MD (Brigham and Women'S Hospital) Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AbbVie. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AC Immune. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acumen. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alector. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biohaven. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Nervgen. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Oligomerix. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Prothena. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ionis. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vaxxinity. An immediate family member of Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. An immediate family member of Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. The institution of Dr. Sperling has received research support from Eli Lilly. The institution of Dr. Sperling has received research support from Eisai. The institution of Dr. Sperling has received research support from NIH.
No disclosure on file
Dorene M. Rentz, PsyD (Brigham and Women's Hospital) Dr. Rentz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Digital Cognition Technologies. Dr. Rentz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Neurotrack.