Abstract Details

Title Fatigue Prevalence and Correlates in a Cohort of Patients with Autonomic Dysfunction

Topic Autonomic Disorders

Presentation(s) P03 - (-)

Poster/Presentation
Number 032

Objective

Background BACKGROUND: Fatigue is a non specific symptom of many disorders. This is different form sleepiness and the more specific symptom of muscle fatigue.

Design/Methods DESIGN/METHODS: 459 patients, 118 men (mean age 47.3 years) and 341 women (with mean age 44.4 years) were diagnosed with clinical autonomic dysfunction. Patients underwent autonomic testing. In addition, patients underwent laboratory workup for potential etiologies and confounding disorders. If muscle fatigue was the main symptom electrophysiological evaluation for a neuromuscular junction disorder, motor neuron disorder or myopathy was performed. If a sleep disorder was clinically suspected overnight polysomnography and if indicated next day multiple sleep latency testing was performed. For the purpose of the presence of fatigue common disorders were ruled out.

Results RESULTS: Fatigue was the main complaint in 24 patients (5.23%). However 323 patients (70.3%) complained of fatigue in addition to other symptoms. Patients with a family history of autonomic dysfunction were more likely to have fatigue compared to those without a family history (78.85% vs. 59.3%, p<0.0001). Patients with sleep disorders were more likely to have fatigue compared to those without sleep disorders (83.73% vs. 46.34%, p<0.0001). Fatigued patients were more likely to be depressed compared to patients without fatigue (25.08% vs. 11.03%, p=0.0007) and also patients with chronic pain were more likely to be fatigued than patients without pain (79.49% vs. 40.74%, p=0.0001) regardless of taking medications that may induce tiredness. Patients with dizziness and fluctuating blood pressures were more likely to have fatigue (80.84% vs. 56.57%, p<0.0001).

Conclusions CONCLUSIONS: Our analysis indicates that fatigue is a common complaint in patients with autonomic dysfunction. More commonly the fatigue is generalized and rarely may present as muscle fatigue, usually associated with muscle pain.

Authors/Disclosures
Alexandru C. Barboi, MD (IU Health Neuroscience Center) PRESENTER	Dr. Barboi has nothing to disclose.
	No disclosure on file
Safwan S. Jaradeh, MD, FAAN (Dept of Neurology)	Dr. Jaradeh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alnylam. Dr. Jaradeh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Akcea. Dr. Jaradeh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alnylam & Akcea. The institution of Dr. Jaradeh has received research support from Alnylam.
Bichun Ouyang	Bichum Ouyang has nothing to disclose.
Mary K. Yellick, RN, NP (Medical College of WI)	No disclosure on file
	No disclosure on file

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