Abstract Details

Title Modifications of Functional Connectivity of the Anterior Cingulum Correlate with Medium-Term Effects of Cognitive Rehabilitation in Patients with Multiple Sclerosis

Topic Neural Repair/Rehabilitation

Presentation(s) P04 - (-)

Poster/Presentation
Number 030

Objective

Background BACKGROUND: Improvements in attentive and executive functions after cognitive rehabilitation was associated to changes of resting state (RS) functional connectivity (FC) of the anterior cingulate cortex (ACC) in RRMS patients.

Design/Methods DESIGN/METHODS: A neuropsychological assessment and RS fMRI at baseline (t0) and after 12 weeks (t1) were obtained from 20 RRMS patients, randomly assigned to treatment group (TG, n=10) or control group (CG, n=10). RS FC of the ACC was assessed with a voxel-wise analysis. Eighteen patients underwent a neuropsychological re-assessment 6 months (t2) after the end of treatment. Generalized linear models were used to evaluate the medium-term efficacy of cognitive rehabilitation and the correlations between neuropsychological scores at t2 and changes of RS FC between t0 and t1.

Results RESULTS: At t2 vs t0, the TG improved at tests of attention, information processing, working memory and semantic fluency (p ranging from <0.0002 to 0.028), while the CG had a stable neuropsychological profile. A significant group x time interaction was found at tests of semantic fluency, attention and executive functions, as well as at quality of life and depression scales (p ranging from 0.004 to 0.04). Significant correlations were found between changes over time of RS FC between of the ACC with the right middle frontal gyrus and right inferior parietal lobule and Wisconsin Card Sorting Test (p=0.04) and Paced Auditory Serial Addition Test3" score (p?0.0001).

Conclusions CONCLUSIONS: In MS patients, neuroplasticity in neural networks subserving the trained functions might contribute to predict the persistence of improvement of cognitive performance following cognitive rehabilitation.

Authors/Disclosures
PRESENTER	No disclosure on file
Alasdair Coles, MD, PhD (University of Cambridge)	Dr. Coles has nothing to disclose.
Maria A. Rocca (Neuroimaging Research Unit)	Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen, Bristol Myers Squibb, Eli Lilly, Janssen, Roche. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZaneca, Biogen, Bristol Myers Squibb, Bromatech, Celgene, Genzyme, Horizon Therapeutics Italy, Merck Serono SpA, Novartis, Roche, Sanofi and Teva. The institution of Maria Assunta Rocca has received research support from MS Society of Canada, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Massimiliano Copetti	No disclosure on file
Paola Valsasina	Paola Valsasina has nothing to disclose.
	No disclosure on file
Flavia Mattioli, MD (University of Brescia)	Dr. Mattioli has nothing to disclose.
Ruggero Capra, MD	Dr. Capra has nothing to disclose.
Giancarlo Comi, MD (University Vita-Salute)	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit)	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.

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