Abstract Details

Title Cognitive Impairment in Patients with Multiple Sclerosis and Its Relation to Clinical Subtype, ��ɫ��, Occupation and Leisure Activities

Topic MS and Related Diseases

Presentation(s) P04 - (-)

Poster/Presentation
Number 117

Objective

Background BACKGROUND: CI and its effects on patients' lives is a central aspect of MS-research.

Design/Methods DESIGN/METHODS: Upon retrospectively evaluating the scores of 27 neuropsychological (NP) tests of 128 MS-patients, we assessed the five subsystems of cognitive abilities (attention, executive functions, visual perception and construction, learning and memory, problem solving and language) to examine their correlation with 1) clinical subtype 2) education 3) occupation 4) physical activity and 5) reading using the Chi-quadrant-, the Kruskall-Wallis- and Mann-Whitney-U-Test.

Results RESULTS: Clinical subtype was connected to the patients' occupation and physical activity, yet not to education or reading activity. It was furthermore associated with patients' test scores in all NP-subsystems that improved from PPMS over SPMS to RRMS patients. Moreover regular physical activity was correlated with improved scores in all NP-subsystems especially in the group engaging in daily running and swimming. Additionally, educational background of MS-patients was associated with CI in all NP-subsystems besides visual perception and construction especially when comparing the group with the lowest educational level with the two higher leveled groups while only memory skills were affected upon comparing the latter two. Furthermore, patients whose occupation demands a high level of independency and abstract-logical thinking scored better results in all NP-subsystems; the effects were more pronounced between the lowest-level group concerning these demands and the medium-level group. Finally, regular reading of challenging material was associated with better test scores while sporadic reading showed little effect.

Conclusions CONCLUSIONS: We demonstrated that 1) clinical subtype of MS is related to CI and lifestyle choices and that 2) education, occupation, sports and reading impact the degree and characteristics of CI. These results will be of importance in terms of future recommendations for affected patients.

Authors/Disclosures
Sophie Gebel, MD PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Gavin Giovannoni, MD (QMUL)	Dr. Giovannoni has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sanofi. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Merck KGaA. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche-Genentech. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Moderna. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sandoz. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Astoria Biologica. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Zenas. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Giovannoni has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Medscape.

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