Abstract Details

Title Continuous Home Monitoring of Essential Tremor Using Motion Sensors

Topic Movement Disorders

Presentation(s) P05 - (-)

Poster/Presentation
Number 035

Objective

Background BACKGROUND: ET is characterized primarily by postural and kinetic tremors. We have previously demonstrated that a motion sensor system can accurately classify and quantify tremor during standardized assessments and routine activities of daily living.

Design/Methods DESIGN/METHODS: Seventeen subjects (10 male, 7 female; age, 48-85; disease duration, 3-60 years) with ET wore a wireless motion sensor containing a triaxial accelerometer and gyroscope on the index finger for up to 10 hours on two consecutive days. Medication usage was unaltered. Mathematical models were used to classify tremor type and quantify tremor severity continuously throughout the day. At one-hour intervals, the subjects also performed previously validated motion sensor-based automated tremor assessments consisting of standardized tasks to evaluate rest, postural, and kinetic tremor on a 0-4 scale. These discrete assessments were used to periodically evaluate the accuracy of the continuous ratings. As tremor severity may fluctuate, agreement between discrete assessments and continuous scores during the immediate ten minutes following each discrete assessment was calculated. Since resting tremor is not common in ET, tremor ratings output during continuous monitoring when no voluntary motion was present were compared to the standardized postural scores, while tremor ratings during voluntary motion were compared to the standardized kinetic tremor scores.

Results RESULTS: Continuous tremor ratings during unconstrained activities immediately following automated motor assessments were correlated with standardized kinetic (R=0.64) and postural (R=0.41) tremor scores. Continuous scores had an average intraday range of 0.94 (kinetic) and 1.19 (postural), reflecting fluctuation in tremor severity.

Conclusions CONCLUSIONS: Tremor scores estimated during unconstrained activities are consistent with scores from standardized assessments. Continuous objective tremor monitoring may have the potential to aid in therapy development and symptom management for patients with ET and other movement disorders.

Authors/Disclosures
PRESENTER	No disclosure on file
Sheila R. Eichenseer, MD (Medical College of Wisconsin)	No disclosure on file
Christopher Goetz, MD, FAAN (Rush University Medical Center)	The institution of Dr. Goetz has received research support from Michael J. Fox Foundation. The institution of Dr. Goetz has received research support from NIH. The institution of Dr. Goetz has received research support from Department of Defense. Dr. Goetz has received publishing royalties from a publication relating to health care. Dr. Goetz has received publishing royalties from a publication relating to health care. Dr. Goetz has received publishing royalties from a publication relating to health care.
Olga Waln, MD (Methodist Neurological Institute)	Dr. Waln has nothing to disclose.
Christine B. Hunter, RN, BSN (PDCMDC)	No disclosure on file
Joseph Jankovic, MD, FAAN (Baylor College of Medicine)	Dr. Jankovic has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Revance. Dr. Jankovic has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Revance, Allergan. The institution of Dr. Jankovic has received research support from Baylor College of Medicine. Dr. Jankovic has received research support from Abbvie. The institution of Dr. Jankovic has received research support from Abbvie.
David Vaillancourt	David Vaillancourt has received personal compensation for serving as an employee of Automated Imaging Diagnostics. David Vaillancourt has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley. The institution of David Vaillancourt has received research support from NIH. David Vaillancourt has received intellectual property interests from a discovery or technology relating to health care.
	No disclosure on file
Joseph Giuffrida, PhD	No disclosure on file
Dustin A. Heldman, PhD (Great Lakes NeuroTechnologies)	Dr. Heldman has received personal compensation for serving as an employee of Great Lakes NeuroTechnologies Inc.. Dr. Heldman has stock in Great Lakes NeuroTechnologies. The institution of Dr. Heldman has received research support from NIH.

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