Abstract Details

Title REM Sleep Atonia - A Marker of Freezing of Gait in Parkinson's Disease

Topic Movement Disorders

Presentation(s) P04 - (-)

Poster/Presentation
Number 167

Objective

Background BACKGROUND: FOG is a common and disabling manifestation of PD. PD patients with REM Sleep Behavior Disorder (RBD) have increased frequency of falls and postural instability. Despite the common networks involved in the pathophysiology of RBD and FOG, associations between RBD and FOG in PD remain poorly understood.

Design/Methods DESIGN/METHODS: Forty, age- and gender-matched participants (RBD n=10, PD without FOG n=10, PD with FOG n=10, controls n=10) underwent polysomnography. Tonic and phasic REM sleep were qantified based on the chin EMG. The tonic EMG activity was scored across 30-second epochs when the chin EMG activity was two times greater than in N3 sleep during >50% of the epoch. The phasic EMG activity was asesssed in 3-seciond mini-epoch. Any burst of EMG activity lasting 0.1-5.0 seconds and with an amplitude exceeding twice the background EMG activity was counted. The phasic REM activity was the sum of mini-epochs with increased muscle activity, divided by the total REM sleep time. Freezing of gait was assessed by the Freezing of Gait Questionnaire. One-way ANOVAs and t test were used to compare REM activity across the groups.

Results RESULTS: Study participants did not differ in total sleep time, sleep efficiency, sleep latency and % of sleep stages. A statistically significant group effects were observed for phasic and tonic EMG activity during REM sleep, respectively (F=15.37, p=0.001; F=14.39, p=0.001). Tonic and phasic muscle activity was significantly increased relative to control subjects in the RBD and PD with FOG groups. Phasic and tonic muscle activity was significantly higher in the PD with FOG group compared with the PD without FOG group (p=0.01; p=0.001).

Conclusions CONCLUSIONS: PD with co-existent FOG is associated with increased tonic and phasic muscle activation during REM sleep. REM-related muscle activity may predict FOG in PD.

Authors/Disclosures
Aleksandar Videnovic, MD, MSc, FAAN (MGH Neurological Clinical Research Institute) PRESENTER	Dr. Videnovic has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Maria Trojano (Policlinico - Bari)	Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi_Genzyme. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Janssen. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sandoz. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi-Genzyme. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Maria Trojano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen.
	No disclosure on file
	No disclosure on file

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