Abstract Details

Title Assessment of Vitamin D Deficiency in Patients with Neurological Disorders

Topic Neural Repair/Rehabilitation

Presentation(s) P03 - (-)

Poster/Presentation
Number 271

Objective

Background BACKGROUND: Vitamin D deficiency has been recently correlated with numerous disorders of the Nervous System.

Design/Methods DESIGN/METHODS: All patients hospitalized between 1 April 2010 and 31 August 2012 underwent blood sample to test vitamin D (25 OH-D) level. The range of the laboratory were: normality between 31 and 100 ng/mL, moderate deficient state between 20 and 30 ng/mL, while levels below 20 ng/mL indicate a deficient state. Logistic regression analysis was performed.

Results RESULTS: 458 patients underwent blood test (240 M and 218 W). Mean age was 58.4 ± 16.5 without differences between sexes (p=0.33). Vitamin D deficiency was detected in 266 patients (58.1%), (138 M and 128 W), mean level was 11.6 ± 4.5 ng/mL, without differences between sexes (p=0.51). Vitamin D deficiency was detected more frequently in patients suffering for ataxic syndromes (72.7%), ALS (66.7%), spine lesions (63.3%), polyneuropathies (63.0%), and stroke (62.6%). In patients over 65 years of age, Vitamin D deficiency was detected more frequently in patients suffering for stroke (77.0%), polyneuropathies (72.7%), traumatic brain injuries (66.6%), spine lesions (64.3%), and Parkinson's disease (64.0%). No significant correlations were identified at the logistic regression analysis (p>0.05 for all categories).

Conclusions CONCLUSIONS: The results of the present study may have been biased by the type of the study population (hospital-based) and the small size of the sample. However, the frequent association between Vitamin D deficiency and neurologic disorders indicates that this vitamin may have a fundamental role in physiologic and pathological processes of the Nervous System, particularly in patients over 65 years of age. Vitamin D deficiency should be investigated routinely in clinical practice as the detection of this parameter may have important therapeutic implications.

Authors/Disclosures
Leonardo Triggiani (Ospedale San Giovanni Battista) PRESENTER	No disclosure on file
Annalisa Barracchini	No disclosure on file
	No disclosure on file
	No disclosure on file
Anita Shanmugham, MS, MPH	No disclosure on file
Pei-Ran Ho	No disclosure on file

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