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Abstract Details

Auditory Startle in Behavioral Variant Frontotemporal Dementia Compared to Alzheimer's Disease and Healthy Controls
Behavioral Neurology
P07 - (-)
167
BACKGROUND: Prior research has shown a reduced auditory startle response in patients with frontotemporal dementia (FTD) as compared to Alzheimer's disease (AD) patients and healthy controls. bvFTD is often misdiagnosed with early onset AD (EAD). It is not known whether the startle response differs between bvFTD patients from those with EAD.
DESIGN/METHODS: Skin conductance (SC) was continuously recorded for 11 behavioral variant FTD, 11 EAD, and 17 age-matched HC. After a baseline period of 5 minutes, an unwarned 115db startle stimulus was administered for 500 milliseconds and a post-startle period was recorded. We compared the characteristics of the SC response (amplitude and peak response time) during the 9 seconds after the startle stimulus.
RESULTS: : No group differences were observed in age, gender, education, ethnicity and Mini Mental State Exam. No significant group differences were observed in peak response time . A one-way ANOVA revealed a significant main effect of group on SC amplitude (F(2,37)=3.46; p=.04). EAD patients showed significantly higher amplitude as compared to bvFTD patients (p=.03) and to HC (p=.02) (Mean amplitude: bvFTD= 0.23 [micro]S (卤0.3); AD= 0.75 [micro]S (卤0.9); HC=0.23 [micro]S (卤0.3)).
CONCLUSIONS: This study found that bvFTD patients had a physiological startle response that did not differ from healthy controls. EAD patients had a larger startle response, possibly reflecting decreased sensorimotor gating from entorhinal pathology. Further studies are needed to evaluate the startle response for purposes of diagnosis.
Authors/Disclosures
Aditi A. Joshi, MD
PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Natalie Kaiser (West Los Angeles VA Medical Center) No disclosure on file
Mario F. Mendez, MD, PhD, FAAN (VA Greater Los Angeles Healthcare System and UCLA) Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medical 好色先生 Speakers' Bureau. Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for UpToDate. The institution of Dr. Mendez has received research support from NIH. Dr. Mendez has received publishing royalties from a publication relating to health care.