Abstract Details

Title Acute Neuroimaging Abnormalities Associated with Post-Traumatic Headache Following Traumatic Brain Injury

Topic Neural Repair/Rehabilitation

Presentation(s) P04 - (-)

Poster/Presentation
Number 020

Objective

Background BACKGROUND: Headache is one of the most commonly reported symptoms occurring in over 70% at some point the first year after TBI and 41% of people report HA at 3,6 and 12 months post-injury. Known risk factors for post-traumatic headache (PTH) are female gender and pre-injury history of HA. It is not known whether type of head trauma is a risk factor for HA occurrence or persistence.

Design/Methods DESIGN/METHODS: Prospective, observational study of 452 consecutive individuals with moderate to severe TBI admitted to 7 TBI Model Systems inpatient rehabilitation units. HA prevalence and characteristics were obtained prior to or within one week of discharge and via telelphone at 3,6 and 12 months post-injury. Acute injury CT (computed tomography) was inventoried for 10 abnormalities (focal cortical/parenchymal contusion, focal/non-cortical contusion, intraventricular hemorrhage (IVH), subarachnoid hemorrhage (SAH), skull, facial or spine fractures, presence of extra-axial fluid, cistern compression/midline shift>5mm). Presence and type of imaging abnormalities at time of injury were examined for any significant association with presence or absence of PTH early as well as persistently across time.

Results RESULTS: SAH was the most common neuroimaging abnormality (70%) followed by cortical contusions and extra-axial fluid collection (60% each) for all individuals with TBI. No significant differences were seen in prevalence of individual imaging findings for those with and without HA and for those with HA early vs persistent in the first year after injury.

Conclusions CONCLUSIONS: Neuroimaging findings in moderate to severe TBI were not found to be related to the presence or absence of PTH, nor to whether HA occurred early or was persistent over time. Further investigation is needed to determine whether neuroimaging findings may be related to specific characteristics of HA.

Authors/Disclosures
Sylvia M. Lucas, MD, PhD (Harborview Medical Center) PRESENTER	No disclosure on file
Jennifer Devine, MD (Consultant)	No disclosure on file
	No disclosure on file
	No disclosure on file
Sureyya Dikmen, PhD (Univ of WA/Dept of Rehab Med)	No disclosure on file
Sean J. Pittock, MD, FAAN (Mayo Clinic Dept of Neurology)	Dr. Pittock has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Arialys. The institution of Dr. Pittock has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. The institution of Dr. Pittock has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB. The institution of Dr. Pittock has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche/Genentech. The institution of Dr. Pittock has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Alexion/AstraZeneka. The institution of Dr. Pittock has received research support from NIH. Dr. Pittock has received intellectual property interests from a discovery or technology relating to health care. Dr. Pittock has received intellectual property interests from a discovery or technology relating to health care. Dr. Pittock has received publishing royalties from a publication relating to health care.

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