Abstract Details

Title Comparison of Respiratory Abnormalities in Epileptic vs. Non-Epileptic Seizures

Topic Epilepsy

Presentation(s) P07 - (-)

Poster/Presentation
Number 169

Objective

Background BACKGROUND: Respiratory dysfunction is frequently seen in association with epileptic-seizures and may be a contributing factor to the higher risk of unexpected death. However, the presence of abnormal respiration associated with non-epileptic events has not been examined.

Design/Methods DESIGN/METHODS: We prospectively enrolled patients admitted in the epilepsy monitoring unit for seizure evaluation. Breathing disturbances (central versus obstructive events, tachypneas versus bradypnea), oxygenation and heart-rate before, during and after seizures and relationship to seizure activity were evaluated by respiratory inductance plethysmography (RIP), pulse-oximetry and EKG. Type of seizure (non-epileptic versus epileptic) was determined on the basis of EEG and video analysis. Statistical analyses were performed to compare minimal oxygen saturation (two group mean comparison test), as well as proportions of apnea, tachycardia, and desaturation in ES versus NES (two groups comparison of proportions).

Results RESULTS: Forty-three adult-patients were enrolled from October 2010 to August 2011. Subjects' age ranged from 22 to 62 years. Fifty-five definite epileptic and 22 non-epileptic events were recorded. Significant desaturation was noted in 54% of the ES and none of the NES. Minimal oxygen saturation associated with an event was significantly lower in the ES compared with the NES (p=.03). Apnea (central or obstructive) was noted in 35% of the ES and none of the NES (p=.001). Tachycardia occurred in 67% of the ES 71% of the NES (n/s).

Conclusions CONCLUSIONS: Our findings complement prior reports of cardiorespiratory abnormalities in epileptic events, in comparison with non-epileptic events. Tachycardia was similar in ES and NES. In contrast, respiratory abnormalities were seen primarily in the epileptic events. This suggests that respiratory dysfunction has a unique importance in the evaluation of epileptic seizures.

Authors/Disclosures
Sanjeev V. Kothare, MD, FAAN (Cohen Children's Hospital, Northwell Health) PRESENTER	Dr. Kothare has nothing to disclose.
Marc Chamberlain, MD (Cascadian Therapeutics)	No disclosure on file
	No disclosure on file
Barbara A. Dworetzky, MD, FAAN (Brigham and Women's Hospital)	Dr. Dworetzky has received publishing royalties from a publication relating to health care.
Myriam Abdennadher, MD (Boston University School of Medicine/Boston Medical Center)	The institution of Dr. Abdennadher has received research support from Grinspoon Foundation. The institution of Dr. Abdennadher has received research support from Boston University CTSI grant. The institution of Dr. Abdennadher has received research support from Alzheimer's Disease Research Center at Boston University. The institution of Dr. Abdennadher has received research support from Alzheimer's Disease Research Center at Boston University. The institution of Dr. Abdennadher has received research support from Reddy/Blackstone.
Milena Pavlova, MD (Brigham and Womens Hospital Dept of Neurology)	Dr. Pavlova has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Pear Therapeutics. Dr. Pavlova has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Oakstone. The institution of Dr. Pavlova has received research support from Jazz. The institution of Dr. Pavlova has received research support from Vanda. The institution of Dr. Pavlova has received research support from Biomobie. Dr. Pavlova has received personal compensation in the range of $500-$4,999 for serving as a Didactic article with Neurodiem.

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