Abstract Details

Title Arterial CNS Involvement in Behcet's Disease

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P05 - (-)

Poster/Presentation
Number 231

Objective

Background BACKGROUND: Behcet's disease is a recurrent systemic inflammatory disorder of unknown etiology. although BD tends to involve vascular structures rather often, the incidence of arterial involvement is far behind that of venous involvement. Arterial CNS involvement is rarely reported in BD.

Design/Methods DESIGN/METHODS: All the files of Neuro-Behcet outpatient clinic of Istanbul Medical Faculty were retrospectively evaluated to sort out the cases with arterial CNS involvement. Demographical findings, clinical characteristics and radiological findings were evaluated.

Results RESULTS: Between 1984 and 2011 there were 18 cases with BD and cranial arterial involvement out of 400 patients with neurological involvement. Four were female and fourteen were male (M:F=3.5). Their age at onset of arterial CNS involvement ranged between 25 and 64 years (median: 42; mean: 42.5 + 11.7). Fifteen patients had presented with acute hemiparesis/hemiplegia, accompanied by aphasia in two, ipsilateral ataxia in one, contralateral brainstem syndrome in two patients. One patient had an asymptomatic intracranial aneurysm. One patient presented with seizures due to anterior cerebral artery territory infarct, and one patient presented with multiple cranial neuropathies due to external carotid aneurysm. One of the female patients was discovered to have an underlying rheumatic mitral stenosis, and three patients were over age 50 which may suggest that stroke may not be directly associated to BD in those four cases. In only two patients vasculitic involvement could be shown on angiography. However, in the remaining patients no etiologies other than BD could be found.

Conclusions CONCLUSIONS: Arterial CNS involvement is rarely seen in BD. A minority of those cases could be shown to have underlying vasculitis. However, other etiological factors unrelated to BD should be sought exclusively in such cases before attributing the stroke to BD.

Authors/Disclosures
PRESENTER	No disclosure on file
Thomas E. Lloyd, MD, PhD (Baylor College of Medicine)	Dr. Lloyd has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier.
Erkingul Birday-Shugaiv	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Erdem Tuzun	Erdem Tuzun has nothing to disclose.
Oguzhan Coban	No disclosure on file
Sara Z. Bahar, MD	No disclosure on file
Daniel Friedman, MD, FAAN (NYU Langone Medical Center)	The institution of Dr. Friedman has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Epilepsy Study Consortium (non-profit). Dr. Friedman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Meili Technology. Dr. Friedman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Neurelis. Dr. Friedman has stock in Neuroview Technology. The institution of Dr. Friedman has received research support from NIH. The institution of Dr. Friedman has received research support from CDC. The institution of Dr. Friedman has received research support from Epitel. The institution of Dr. Friedman has received research support from Neuropace. The institution of Dr. Friedman has received research support from Rapport Therapeutics. Dr. Friedman has received intellectual property interests from a discovery or technology relating to health care. Dr. Friedman has received intellectual property interests from a discovery or technology relating to health care. Dr. Friedman has received publishing royalties from a publication relating to health care. Dr. Friedman has received personal compensation in the range of $500-$4,999 for serving as a Speaker Honorarium with SK Life Sciences. Dr. Friedman has received personal compensation in the range of $500-$4,999 for serving as a Speaker Honorarium with AAN. Dr. Friedman has received personal compensation in the range of $500-$4,999 for serving as a Travel Reimbursement with Epilepsy Foundation of America.

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