Abstract Details

Title Predictors of Good Clinical Outcome in Acute Stroke Patients Underwent Recanalization Therapy

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P01 - (-)

Poster/Presentation
Number 242

Objective

Background BACKGROUND: Early recanalization of brain artery occlusion predicts 3-month independency in acute ischemic stroke (AIS) patients. Mechanical recanalization methods are experimentally tested in AIS treatment.

Design/Methods DESIGN/METHODS: Altogether 343 patients (190 males; mean age 60.0±13.3 years) with AIS due to middle cerebral artery and/or internal carotid artery (ICA) occlusion indicated to mechanical recanalization were included into the study. Site of arterial occlusion, NIHSS at admission, type of intervention, recanalization using 6-grade TICI scale, early neurological improvement (ENI), occurrence of symptomatic intracerebral hemorrhage (SICH) and brain edema on control CT, vascular risk factors (age, gender, history hypertension, diabetes mellitus, hyperlipidemia, atrial fibrillation), blood pressure, blood level of glucose and cholesterol, antithrombotic and statin therapy, and modified Rankin score (mRS) at day 90 were evaluated and analyzed using Spearman's correlation coefficient, univariate and multivariate logistic regressions. Good clinical outcome was defined as mRS 0-2.

Results RESULTS: Lower age (r=0.22, p<0.001), NIHSS at admission (r=0.37, p<0.001), time to recanalization (r=0.17, p<0.001) and blood level of glucose (r=0.20, p<0.001) significantly correlated with better clinical outcome. Good clinical outcome was significantly more frequent also in patients with ENI (p<0.001) or higher TICI grade (p<0.001) and less frequent in patients with T-occlusion of ICA, SICH or brain edema on control CT (p<0.001 in all cases). Multivariate logistic regression analysis identified 3 predictors of good clinical outcome at day 90: NIHSS at admission (RR=0.87 per 1 point in NIHSS; p=0.03), recanalization grade (RR=1.47 per 1 grade in TICI scale; p=0.04) and ENI (RR=44.88; p<0.0001).

Conclusions CONCLUSIONS: NIHSS at admission, recanalization grade and early neurological improvement are independent predictors of clinical outcome in AIS patients underwent mechanical recanalization.

Authors/Disclosures
David Skoloudik, MD, PhD (University Hospital Ostrava) PRESENTER	No disclosure on file
	No disclosure on file
Bruce A. Cohen, MD, FAAN (Northwestern University, Feinberg School of Medicine)	Dr. Cohen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Cohen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for EMD Serono. Dr. Cohen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mylan. The institution of Dr. Cohen has received research support from Genentech. The institution of Dr. Cohen has received research support from MedDay. The institution of Dr. Cohen has received research support from Consortium of Multiple Sclerosis Centers.
	No disclosure on file
	No disclosure on file
Daniel Sanak	No disclosure on file
	No disclosure on file
	No disclosure on file

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