Abstract Details

Title Long Term Outcomes of Clinically Isolated Syndrome in Hong Kong

Topic MS and Related Diseases

Presentation(s) P04 - (-)

Poster/Presentation
Number 138

Objective

Background BACKGROUND: Clinically isolated syndrome (CIS) is regarded as a preceding event of multiple sclerosis (MS) and neuromyelitis optica (NMO), which are both severely disabling conditions. There is scarcity of data on the conversion rate of CIS patients into MS or NMO, as well as their long term prognosis in the Asian population.

Design/Methods DESIGN/METHODS: Between June 1997 and May 2007, 69 consecutive patients who presented with CIS were prospectively recruited into a cohort. The clinical characteristics, baseline MRI brain and spine and other investigation results were recorded. MRI brain was defined as abnormal if there were any lesions present. The 2005 McDonald's and Wingerchuk criteria were used to diagnose MS and NMO respectively. The most updated status of all subjects was determined as of September 2012.

Results RESULTS: Among the 69 subjects, 22 converted into MS (31.9%), 8 into NMO (11.6%), and 39 remained as monophasic disease (56.5%) after a mean duration of 8.02 years. 37 (53.6%) patients had abnormal baseline MRI brain, of which 22 progressed into MS (59.5%), 4 into NMO (10.8%), and 11 (29.7%) remained as monophasic disease. Of the MS group, 8 (36.4%) died or progressed into EDSS >=6.0, while 14 (63.6%) remained independent after a mean duration of 8.93 years. For NMO patients, 5 (62.5%) progressed into EDSS >=6.0 or died. In the 39 patients who remained as monophasic disease, 32 (82.1%) were still independent after a mean duration of 8.81 years.

Conclusions CONCLUSIONS: Compared with Caucasian patients, CIS patients in Hong Kong have similar conversion rate into chronic demyelinating diseases (MS or NMO). Both MS and NMO patients in our cohort had worse long term outcomes.

Authors/Disclosures
Stephen W. Cheng, MD PRESENTER	No disclosure on file
Richard Li, MD	No disclosure on file
Ka Lock Shiu, MBBS, MRCP (Hong Kong Sanatorium & Hospital)	No disclosure on file
	No disclosure on file
Lloyd H. Kasper, MD (Dartmouth Medical School)	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file

��ɫ��

��ɫ��