Abstract Details

Title Can Childhood Comorbidities Be Good Predictors of Functional Outcome in Adults with Tourette Syndrome? A Series of 140 Cases

Topic Movement Disorders

Presentation(s) P02 - (-)

Poster/Presentation
Number 061

Objective

Background BACKGROUND: Tourette syndrome (TS) is a childhood-onset neuropsychiatric condition characterised by multiple motor and phonic tics. Comorbid behavioural problems are common, especially ADHD or OCD or both. Little is known about the long-term prognosis of TS associated with these comorbidities.

Design/Methods DESIGN/METHODS: Retrospective chart review of over 30 years (1981- 2011). Inclusion: Cases satisfying TS core diagnostic criteria seen in pediatric neurology clinic and followed up as adult. Exclusion: other neurological findings, abnormal neuroimaging or metabolic studies. Cases were reviewed for age, sex, family history, tic characteristics, associated ADHD or OCD, level of education, occupation and marital status. The patients were divided into Group A (TS with ADHD or OCD) and Group B (TS without ADHD or OCD). Adults with education of college degree, married and employed were considered to have good functional outcome.

Results RESULTS: Of 140 patients seen in TS clinic, 113 were males and 27 were females. Mean age of symptom onset was 8.5 years. Of all cases, 55 had mild, 71had moderate, 14 had severe tics. Group A: 95 cases (67%), mean age 8 year, 85 males. Of them 40 (42%) were college graduates, married and employed. Group B: 45 cases (33%), mean age 10 year, 28 males. Of them 16 (35%) were college graduates, married and employed. There was no statistically significant difference in functional outcome between group A and group B.

Conclusions CONCLUSIONS: In TS associated co-morbidities (ADD or OCD) do not predict functional outcome in adults compared to those without co-morbidities, however, further comprehensive age specific assessment of functional impairment in larger population might be necessary.

Authors/Disclosures
Gayatra Mainali, MD (Penn State Health) PRESENTER	Dr. Mainali has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Origin Biosciences.
Lauren M. Oommen, DO (UCSF)	No disclosure on file
Richard J. Lederman, MD, PhD, FAAN (retired)	No disclosure on file
Gerald Erenberg, MD, FAAN	No disclosure on file
Nicolas Mavroudakis, MD, PhD (Hopital Erasme)	No disclosure on file

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