Abstract Details

Title Obstructive Sleep Apnea Increases Risk of Incident Dementia in Community-Dwelling Older Adults

Topic Aging and Dementia

Presentation(s) P03 - (-)

Poster/Presentation
Number 098

Objective

Background BACKGROUND: Obstructive sleep apnea (OSA) is common in dementia and is also associated with cognitive impairment among non-demented individuals. A recent study reported that OSA is a risk factor for incident dementia among elderly women, but there are no reports of whether this risk is independent of gender.

Design/Methods DESIGN/METHODS: Participants in the Sleep Heart Health Study who were also enrolled in the Cardiovascular Health Study were included. Presence of OSA was detected by ambulatory polysomnography in 1997-1998, and defined as apnea and hypopnea index (with 4% SpO2 desaturations) ?5/hour. Cognitive status was carefully adjudicated in 1998-1999, as previously described. Only participants with normal cognitive status at this time were included in the analysis. Yearly assessments provided information regarding onset of dementia and vital status. Data were censored at 2006. Time to dementia was compared between those with and without OSA, using Cox regression. Results were adjusted for gender, age, and Apoe?4 allele status.

Results RESULTS: In this older, community based, cognitively-normal sample (n=208, mean age 76.9 ±3.6 years, 40% male), OSA was diagnosed in 110 (53%). Dementia developed in 109 (52%) participants. Of the 56 (27%) participants who died by 2006, 25 (12%) had developed dementia and were censored at time of dementia diagnosis. OSA was independently associated with dementia diagnosis (Hazard Ratio (HR)=1.65, 95% CI=1.10-2.48, p=0.017) after adjustment for female gender (HR=1.57, p=0.043), age (HR=1.09, p=0.002), and Apoe?4 allele (HR=1.56, p=0.042).

Conclusions CONCLUSIONS: OSA increased prospective risk of dementia in an older cohort of men and women independent of age, gender, and Apoe?4 allele status.

Authors/Disclosures
Yo-El Ju, MD PRESENTER	The institution of Dr. Ju has received research support from National Institutes of Health.
Oscar L. Lopez, MD, FAAN	Dr. Lopez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acumen.
	No disclosure on file
Charles C. Flippen II, MD, FAAN (UCLA Goldberg Migraine Program)	Dr. Flippen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Carelon. Dr. Flippen has a non-compensated relationship as a committee member with American Headache Society that is relevant to AAN interests or activities. Dr. Flippen has a non-compensated relationship as a committee/task force member with American Neurological Association that is relevant to AAN interests or activities.
Charles C. Flippen II, MD, FAAN (UCLA Goldberg Migraine Program)	Dr. Flippen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Carelon. Dr. Flippen has a non-compensated relationship as a committee member with American Headache Society that is relevant to AAN interests or activities. Dr. Flippen has a non-compensated relationship as a committee/task force member with American Neurological Association that is relevant to AAN interests or activities.
Jordan S. Dubow, MD	Dr. Dubow has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Revalesio .
	No disclosure on file

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