Abstract Details

Title Cerebrovascular Resistance and Cognitive Decline: Modulating Effects of Age

Topic Aging and Dementia

Presentation(s) P07 - (-)

Poster/Presentation
Number 135

Objective

Background BACKGROUND: Aging is associated with elevated blood pressure (BP) and reduced cerebral blood flow (CBF), suggesting elevation in cerebrovascular resistance (CVR), defined as the ratio of BP to CBF. We recently reported CVR elevation associated with dementia and cerebrovascular lesions. The current study compared young-old and very-old adults on CVR, and tested the interaction between CVR and age in the prediction of cognitive decline.

Design/Methods DESIGN/METHODS: Seventy nondemented older adults [19 very old (age >=80); 51 young old (age 60-79)] underwent baseline neuroimaging and one year follow-up cognitive testing. Regional CVR was estimated by dividing participant resting BP by regional CBF, acquired by arterial spin-labeling MRI. The dementia rating scale indexed global cognition. ANCOVA compared very-old and young-old participants on regional CVR. Multiple regression examined the interaction between age and CVR in predicting cognition at one year follow-up. Analyses controlled for age, gender, education, apoE genotype, antihypertensive medications, and vascular risk factors.

Results RESULTS: Very-old participants exhibited elevated thalamus CVR relative to the young-old, F(6,63)=8.84, p=.004, [eta]2=.12. There was a significant age by thalamus CVR interaction predicting cognition, with thalamus CVR elevation being associated with worse cognition in very-old, but not young-old, participants, ?R2=.14, ?=-2.25, p=.0002. Similar interactions were found within the caudate (?R2=.07, ?=-1.78, p=.01), posterior cingulate cortex (?R2=.08, ?=-1.64, p=.007), medial temporal (?R2=.11, ?=-1.93, p=.002), inferior parietal (?R2=.05, ?=-1.32, p=.045), and frontal (?R2=.09, ?=-1.59, p=.003) lobes.

Conclusions CONCLUSIONS: Aging is associated with CVR elevation. Age also modulates the relationship between CVR elevation and cognitive decline, with CVR elevation being associated with cognitive decline in the very-old, but not the young-old. Findings suggest that the vascular contribution to cognitive decline may be more important in the very-old than in the young-old.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Antonio M. Omuro, MD, FAAN (Stanford University)	Dr. Omuro has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ono Therapeutics. Dr. Omuro has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Telix. Dr. Omuro has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Curevac. The institution of Dr. Omuro has received research support from NIH. The institution of Dr. Omuro has received research support from Arcus Biosciences. The institution of Dr. Omuro has received research support from Denovo Biopharma. The institution of Dr. Omuro has received research support from Ono Pharmaceutical. The institution of Dr. Omuro has received research support from Servier. The institution of Dr. Omuro has received research support from Nanopharmaceuticals. The institution of Dr. Omuro has received research support from Denovo.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Mark W. Bondi, PhD	No disclosure on file

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