Abstract Details

Title Apathy Is Associated with Inferior Temporal Atrophy in Amnestic Mild Cognitive Impairment and Clinically Normal Elderly

Topic Aging and Dementia

Presentation(s) P07 - (-)

Poster/Presentation
Number 149

Objective

Background BACKGROUND: Apathy, characterized by loss of goal oriented behavior, is commonly associated with Alzheimer's disease AD dementia and MCI. Apathy has been shown to correlate with regional cortical atrophy in AD dementia, especially in medial frontal regions. We hypothesized that such apathy-associated medial frontal atrophy may begin in AD during or even before the stage of MCI. If true, such apathy-associated atrophy may be a useful biomarker for clinical trials involving the earliest stages of AD.

Design/Methods DESIGN/METHODS: Sixty-six (47 MCI, 19 CN) subjects participated in an investigator-initiated imaging study. Apathy was assessed using the Apathy Evaluation Scale. Cortical thickness of four regions of interest (ROI)[mdash]the bilateral rostral anterior cingulate cortex, inferior temporal cortex, orbitofrontal cortex, and supramarginal cortex[mdash]was assessed with volumetric magnetic resonance imaging. A linear regression model with backward elimination was employed using apathy score as the dependent variable; predictors included cortical thickness of each ROI and the following covariates: diagnosis, age, American National Adult Reading Test IQ (a proxy of premorbid intelligence), Digit Symbol Score (a test of processing speed), and the Rey Auditory Verbal Learning Test total learning score (a test of memory).

Results RESULTS: We found a significant association between greater apathy and decreased thickness of the inferior temporal cortex (p=0.004) and increased thickness of the anterior cingulate cortex (p=0.04) across all subjects. The association between decreased inferior temporal thickness and greater apathy persisted when looking at MCI subjects alone (p=0.02) and CN subjects alone (p=0.04).

Conclusions CONCLUSIONS: Inferior temporal cortical atrophy may be associated with increased apathy in the earliest stages of AD preceding dementia, in contrast to anterior cingulate atrophy that has been associated with apathy at the stage of dementia.

Authors/Disclosures
Brendan J. Guercio (Harvard Medical School) PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Martin Berghoff, MD, FAAN (BundeswehrZentralkrankenhaus Koblenz)	Dr. Berghoff has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen Idec. Dr. Berghoff has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Berghoff has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Berghoff has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MerckSerono. Dr. Berghoff has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb.
	No disclosure on file
	No disclosure on file
Rebecca E. Amariglio (Brigham and Woman's Hospital)	Ms. Amariglio has nothing to disclose.
Dorene M. Rentz, PsyD (Brigham and Women's Hospital)	Dr. Rentz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Digital Cognition Technologies. Dr. Rentz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Neurotrack.
	No disclosure on file
Keith A. Johnson, MD (MGH)	Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AC Immune. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Shionogi. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Prothena. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NervGen. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Oligomerix. Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AC Immune. The institution of Dr. Johnson has received research support from National Institute on Aging. The institution of an immediate family member of Dr. Johnson has received research support from Alzheimer's Association. The institution of an immediate family member of Dr. Johnson has received research support from Eli Lilly and Co. The institution of Dr. Johnson has received research support from Eisai. The institution of an immediate family member of Dr. Johnson has received research support from Eisai.
Reisa A. Sperling, MD (Brigham and Women'S Hospital)	Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AbbVie. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AC Immune. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acumen. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alector. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biohaven. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Nervgen. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Oligomerix. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Prothena. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ionis. Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vaxxinity. An immediate family member of Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. An immediate family member of Dr. Sperling has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. The institution of Dr. Sperling has received research support from Eli Lilly. The institution of Dr. Sperling has received research support from Eisai. The institution of Dr. Sperling has received research support from NIH.
Gad Marshall, MD (Brigham and Women's Hospital)	Dr. Marshall has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ono Pharma USA Inc. Dr. Marshall has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Beth Israel Deaconness Medical Center. Dr. Marshall has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Harvard Health Publications.

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