Abstract Details

Title Naming in Primary Progressive Aphasia: The Contribution of the Temporal Lobe

Topic Aging and Dementia

Presentation(s) P03 - (-)

Poster/Presentation
Number 088

Objective

Background BACKGROUND: Picture naming involves a number of cognitive processes, from visual recognition to lexical-semantic retrieval and phonological encoding. PPA is a neurodegenerative syndrome characterized by progressive atrophy of the left hemisphere language network primarily leading to naming deficits. A number of recent imaging studies on PPA and vascular patients have produced contradictory results with respect to the neural correlates of naming abilities.

Design/Methods DESIGN/METHODS: Thirty PPA patients (7 non fluent/agrammatic; 12 logopenic, and 11 semantic; mean age: 66.9; mean disease duration: 3.3 years) were tested on the DO80 picture naming test. We explored the relationship between naming performance and gray matter (GM) volume by collapsing across subject groups and using the VBM regression method. A significance threshold of p <0.05 (FWE) was accepted.

Results RESULTS: Seventy percent of PPA patients (N=21) showed abnormal naming performance. Performance was positively correlated with GM volume in the left anterior-superior temporal gyrus (posterior to the temporal pole) and in the left posterior-ventral part of inferior temporal cortex. Correlations using other language measures, such as verbal discrimination or phonemic paraphasias, produced no significant results within these two cortical regions.

Conclusions CONCLUSIONS: Our findings suggest that two regions within the temporal lobe play a central role in picture naming, namely superior-anterior and posterior-ventral cortices. We hypothesize that the latter region contributes to visual recognition, whereas the superior-anterior temporal cortex supports lexico-semantic processes. Given that this region is posterior to the temporal pole (known to be implicated in amodal semantics), we suggest its involvement in language-specific processing of semantic information. Within this framework, the superior-anterior temporal cortex, that is not part of classical brain-language models, should be taken into account in novel network-based models.

Authors/Disclosures
Raffaella Migliaccio (Hopital de la Pitie-Salpetriere) PRESENTER	Raffaella Migliaccio has nothing to disclose.
	No disclosure on file
Giancarlo Comi, MD (University Vita-Salute)	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Bruno Dubois, MD (Hopital La Salpetriere)	No disclosure on file
	No disclosure on file
	No disclosure on file

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