Abstract Details

Title Relation of Intracranial Stenosis and Elevated Carotid Intimal Medial Thickness in Black Caribbean Ischemic Stroke Patients

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P03 - (-)

Poster/Presentation
Number 187

Objective

Background BACKGROUND: In Caribbean blacks (CBs) stroke population the rate of intracranial atherosclerosis has been found to be 12-fold higher than that of extracranial atherosclerosis. Carotid intima-media thickness (CIMT) is a generalized marker of vascular disease. This study investigates the direct association of CIMT and intracranial stenosis in CB ischemic stroke population.

Design/Methods DESIGN/METHODS: A pilot, retrospective study was performed to compare the clinical and radiological information of patients presenting with acute stroke symptoms in a community in July through March 2012. Increased mean MCA velocity of symptomatic patients (defined > 80cm/sec) was measured by transcranial doppler. CIMT (increased defined > 0.1cm) was measured on B-mode ultrasound. CIMT was measured blinded to MCA velocities. Univariate analysis by Chi-square (Fisher test) and multivariate analysis by binary logistic regression were performed with SPSS.

Results RESULTS: Of 47 patients, 27 (57%) patients were diagnosed with anterior circulation stroke; mean age 65 years +/- 13.69 (range 28 - 88); 34% male. There was a significant association of increased MCA mean velocity and elevated CIMT [x2 = 3.939, p = 0.026]. Hypercholesterolemia was significantly associated with increased MCA velocity [x2 = 5.639, p = 0.026]. Factors associated with elevated CIMT were a history of hypercholesterolemia [x2 = 5.805, p = 0.012] and hypertension [x2 = 6.810, p = 0.043]. Logistic regression was performed on history of hypercholesterolemia and elevated CIMT with increased MCA mean velocity failed to reveal independent effects.

Conclusions CONCLUSIONS: Our preliminary results suggest that increased MCA velocity is independent elevated CIMT, a biomarker for atherosclerosis, in anterior circulation ischemic stroke in CBs. History of hypercholesterolemia appears to be an important risk factor in atherosclerosis in CBs. This data suggests further prospective studies of MCA stenosis mechanisms in CBs are warranted.

Authors/Disclosures
Susan W. Law, DO (NYC HEALTH AND HOSPITAL / KINGS COUNTY) PRESENTER	Dr. Law has nothing to disclose.
Qing Hao, MD (Duke University School of Medicine)	No disclosure on file
Diana Rojas-Soto, MD (Dartmouth- Hitchcock Medical Center)	Dr. Rojas-Soto has nothing to disclose.
Kottil W. Rammohan, MD (University of Miami)	Dr. Rammohan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Rammohan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. Dr. Rammohan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Genentech. Dr. Rammohan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion. Dr. Rammohan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genzyme. Dr. Rammohan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for EMD Serono. The institution of Dr. Rammohan has received research support from Genentech. The institution of Dr. Rammohan has received research support from Genzyme. The institution of Dr. Rammohan has received research support from EMD Serono. The institution of Dr. Rammohan has received research support from Alexion.
Hua Yu	No disclosure on file
Alison Baird, MBBS, PhD, FRACP, MPH (SUNY Downstate Medical Center)	The institution of Dr. Baird has received research support from NIH. The institution of Dr. Baird has received research support from NIH. The institution of Dr. Baird has received research support from Research Foundation of SUNY. Dr. Baird has received intellectual property interests from a discovery or technology relating to health care. Dr. Baird has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Maimonides Medical Center.

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