Abstract Details

Title The Use of Selective Serotonin Reuptake Inhibitors (SSRIs) May Increase the Risk of Dementia in Patients with Late Life Depression

Topic Aging and Dementia

Presentation(s) P03 - (-)

Poster/Presentation
Number 104

Objective

Background BACKGROUND: Few studies have looked at the association between antidepressant medication and risk of dementia, and those that do have not controlled for depression, cognitive impairment, or concomitant use of dementia medication.

Design/Methods DESIGN/METHODS: Members of the Swedish Twin Registry aged 65 and above were evaluated for cognitive status and depression. Information on antidepressant and dementia medication use was determined from the Swedish Prescription Drug Register (PDR) while dementia was determined from the Swedish National Patient and Death registers. Cox proportional hazards models were used to determine whether antidepressant medication use was associated with dementia, and whether the association was dependent on the onset of depression. Subtypes of antidepressant medications were also evaluated for their association with dementia.

Results RESULTS: A total of 9,112 individuals with information on CIND (Cognitive impairment no dementia), SCI (subjective cognitive impairment) and depression status were identified as being non-demented at the start of the PDR. Of these individuals, 1,477 (16.2%) individuals received antidepressant medications alone, 186 (2.0%) received dementia medications alone, and 120 (1.3%) received both antidepressant and dementia medication. In this study, we found antidepressant use, particularly the use of Selective Serotonin Reuptake Inhibitors (SSRIs) (HR 2.76 CI 1.39-5.50), was associated with an increased risk of dementia in persons with late life depression.

Conclusions CONCLUSIONS: As late life onset of depression may be a prodrome of dementia rather than a risk factor, treating patients with depression as a manifestation of prodromal dementia with antidepressants, particularly with SSRIs, may tip them to manifest dementia rather than protect them.

Authors/Disclosures
Kaavya Narasimhalu, MD, PhD (Singapore General Hospital) PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Elka Stefanova	No disclosure on file
Laura Fratiglioni (Division of Geriatric Medicine, B84)	No disclosure on file
	No disclosure on file
	No disclosure on file

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