Abstract Details

Title Brain MRI Morphometric Changes in Essential Tremor Versus Controls

Topic Movement Disorders

Presentation(s) P05 - (-)

Poster/Presentation
Number 036

Objective

Background BACKGROUND: ET is characterized by postural and kinetic tremors that are thought to arise from aberrant oscillatory motor networks in the brainstem and cerebellum. Efforts to identify morphometric changes in the ET brain using MRI have been mixed, with some groups finding no differences and others finding reduced cerebral and cerebellar gray matter volumes.

Design/Methods DESIGN/METHODS: We studied an ET group (n=16) using 3D T1-weighted MRI at 3T and age and gender-matched control data (n=48) obtained from the Northern Manhattan Study collected using 1.5T MRI. Automated segmentation and parcellation were performed using Freesurfer software (Fischl) and regional cortical thickness measures and volumes were used to examine group-specific differences. Analysis of variance was performed to identify significant differences, with regional changes listed in descending order of percent change.

Results RESULTS: ET and control groups were well-matched (p=0.81), with equivalent standard deviations suggesting that differences in MRI equipment were unlikely to account for observed differences. Regions showing greatest change in volume in the ET group compared to controls were: posterior corpus (-11.7%), L pallidum (-11.7%), R pallidum (-9.7%), R putamen (-8.9%), Brainstem (-5.6%), and 4th ventricle (+23.1%). Regional changes in cortical thickness showed widespread reductions of cortical thickness in the ET group, with exception of the temporal lobes which showed greater reductions in our control group.

Conclusions CONCLUSIONS: We found reductions in brain volume involving the corpus callosum, basal ganglia and brainstem. These findings along with the widespread reductions in cortical thickness provide further validation that ET impacts widespread brain regions. Larger studies are needed to correlate disease phenotypes with changes on neuroimaging.

Authors/Disclosures
Fatta B. Nahab, MD, FAAN (UCSD) PRESENTER	Dr. Nahab has received personal compensation for serving as an employee of Neuron23. Dr. Nahab has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Encora. Dr. Nahab has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for ActualSignal. Dr. Nahab has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Attune Neurosciences, Inc.. Dr. Nahab has stock in Biogen. Dr. Nahab has received personal compensation in the range of $500-$4,999 for serving as a DSMB Member with NIH.
	No disclosure on file
	No disclosure on file
Clinton B. Wright, MD, FAAN (NINDS)	An immediate family member of Dr. Wright has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Wright has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Abali Milne Kalil. Dr. Wright has received publishing royalties from a publication relating to health care. An immediate family member of Dr. Wright has received personal compensation in the range of $500-$4,999 for serving as a surveyor with ASTRO.
	No disclosure on file
	No disclosure on file
	No disclosure on file

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