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Abstract Details

Noninvasive Motor Evoked Potentials with Surface Stimulation in Rodents
Clinical Neurophysiology
P07 - (-)
188
BACKGROUND: Motor evoked potentials are used routinely in clinical practice to assess the integrity of the spinal cord during surgery, and in many diseases. Motor evoked potentials (MEPs) can be obtained by stimulation of the brain with recording over a skeletal muscle or peripheral nerve.
DESIGN/METHODS: In this study, MEPs were obtained on rats with normal myelin as well as dysmyelinated rats, using surface stimulation. A Neuromax EMG machine (NeuroMax, Excel Tech, Oakville, Ontario, Canada), was used to deliver constant voltage stimulation through disposable electrodes.
RESULTS: Motor evoked potentials were consistently elicited in 2 groups of rats - (1) rats with normal myelin (LE rats) and (2) demyelinated rat model with diminished myelin in the central nervous system (LES rats). The mean onset latency and amplitude were 5.66 卤 0.48 and 1.99 卤 0.51 for LE rats, and 5.24 卤 0.81 and 1.68 卤 0.45 for LES rats respectively.
CONCLUSIONS: In conclusion, it is possible to record motor evoked potentials with surface stimulation and recording in rodents.
Authors/Disclosures
William A. Graham, PhD (McMaster University - Hamilton General Site)
PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Daniel H. Selchen, MD (St.Michael'S Hospital) Dr. Selchen has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for EMD Serono. Dr. Selchen has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Roche. Dr. Selchen has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Novartis. Dr. Selchen has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Teva.